School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.
Melbourne Dental School, University of Melbourne, Carlton, VIC, Australia.
Int J Pharm Pract. 2022 Dec 31;30(6):548-553. doi: 10.1093/ijpp/riac051.
Xerostomia is a subjective sensation of dry mouth associated with many medications and increases the risk of tooth decay and other oral complications. The aim of this study was to identify unreported medications associated with dry mouth from the Australian Database of Adverse Event Notifications (ADAEN) from the Therapeutic Goods Administration (TGA) in Australia.
This was a descriptive retrospective study. A request was made to the TGA to provide all reports associated with dry mouth. De-identified reports were provided from the commencement of the database in 1971 until June 2020. Drugs were divided into established drugs that are associated with xerostomia in the primary literature and secondary drugs not reported in the primary literature.
There were 1927 individual case reports for dry mouth associated with medications. Of these, there were 1379 reports of established (primary) drugs and 1481 reports of secondary drugs associated with xerostomia. Dry mouth was found to be associated with many medication classes; analgesics, cardiovascular and gastrointestinal drugs had the greatest number of secondary drugs reported.
A comprehensive list of suspected medications associated with xerostomia has been established. This adds to the growing catalogue of medications associated with dry mouth, where several medications have not previously been identified in the primary literature.
口干是一种与许多药物相关的主观口腔干燥感，会增加龋齿和其他口腔并发症的风险。本研究的目的是从澳大利亚治疗用品管理局（TGA）的澳大利亚不良事件通知数据库（ADAEN）中确定未报告与口干相关的药物。
这是一项描述性回顾性研究。TGA 被要求提供所有与口干相关的报告。从数据库于 1971 年开始运行到 2020 年 6 月，提供了去识别报告。药物分为与原发性文献中口干相关的既定药物和原发性文献中未报告的次要药物。
有 1927 份与药物相关的口干的个别病例报告。其中，有 1379 份是既定（主要）药物的报告，有 1481 份是与口干相关的次要药物的报告。口干与许多药物类别有关；镇痛药、心血管和胃肠道药物报告的次要药物最多。
已经确定了与口干相关的可疑药物的综合清单。这增加了与口干相关的越来越多的药物目录，其中一些药物以前在原发性文献中没有被发现。
