Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Department of Pediatric Gastroenterology and Nutrition, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Pediatr Dermatol. 2023 Jan;40(1):64-68. doi: 10.1111/pde.15110. Epub 2022 Sep 1.
BACKGROUND/OBJECTIVE: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Research suggests an association between obesity and AD, although evidence is lacking from Latin American populations. This study evaluated the association of obesity with AD in children from Chile, a country with high obesity prevalence.
A case-control study was performed in children with active AD (cases) and healthy controls (HCs) from Santiago, Chile. Body mass index was evaluated by z-score (z-BMI), with overweight defined as z-BMI ≥+1 and <+2, and obesity as z-BMI ≥+2. Abdominal obesity was defined by a waist circumference-to-height ratio (WHR) ≥0.5. AD severity was evaluated by Scoring AD (SCORAD) index.
A total of 174 children with AD and 101 controls were included. AD patients had similar overweight (27% vs. 28%) and obesity (21% vs. 26%) rates as HCs (p = .65). Abdominal obesity rates were also comparable (64% vs. 62%, p = .81). In sex-specific analyses, girls with AD had higher abdominal obesity rates than HCs (71% vs. 53%, p < .05) while boys with AD had lower abdominal obesity rates than HCs (53% vs. 75%, p = .03). Among children with AD, higher z-BMI or WHR did not correlate with higher SCORAD, eosinophil counts or total IgE.
In our study, Chilean children with AD had high but similar rates of obesity as HCs, but showed sex-specific associations of abdominal obesity and AD. Further research is needed to evaluate these associations and the roles that weight excess and weight loss could play in the pathogenesis and treatment of AD.
背景/目的：特应性皮炎（AD）是一种慢性炎症性皮肤病。研究表明肥胖与 AD 之间存在关联，尽管来自拉丁美洲人群的证据不足。本研究评估了肥胖与智利儿童 AD 之间的关联，智利是一个肥胖流行率较高的国家。
在智利圣地亚哥进行了一项 AD 活跃儿童（病例）和健康对照（HCs）的病例对照研究。通过 z 评分（zBMI）评估体重指数，超重定义为 zBMI ≥+1 且 <+2，肥胖定义为 zBMI ≥+2。通过腰围身高比（WHR）≥0.5 定义腹型肥胖。AD 严重程度通过 SCORAD 指数评估。
共纳入 174 例 AD 患儿和 101 例对照。AD 患者的超重（27%与 28%）和肥胖（21%与 26%）率与 HCs 相似（p =.65）。腹型肥胖率也相似（64%与 62%，p =.81）。在性别特异性分析中，AD 女孩的腹型肥胖率高于 HCs（71%与 53%，p <.05），而 AD 男孩的腹型肥胖率低于 HCs（53%与 75%，p =.03）。在 AD 患儿中，更高的 zBMI 或 WHR 与更高的 SCORAD、嗜酸性粒细胞计数或总 IgE 无关。
在本研究中，智利 AD 儿童的肥胖率较高，但与 HCs 相似，但表现出与腹型肥胖和 AD 相关的性别特异性关联。需要进一步研究来评估这些关联以及体重增加和减轻在 AD 发病机制和治疗中的作用。
