Son Mi Ju, Yang Geum-Jin, Jo Eun-Heui, Shim Yu-Hwa, Kang Su-Jin, Hong Ji-Eun, Kim Young-Eun, Lee Jung-Eun, Chun Jaemoo, Park Seonghwan, Jung Jeeyoun, Park Min-Cheol
Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon.
Korean Medicine Dermatology Clinical Research Center of Wonkwang University, Iksan.
Medicine (Baltimore). 2019 Jul;98(29):e16527. doi: 10.1097/MD.0000000000016527.
Several studies have found that obesity is associated with atopic dermatitis (AD); however, the mechanisms underlying the association are largely unknown. This study aims to assess the association of AD with obesity in the Korean population and verify its mechanism via a multi-omics analysis.
A case-control study will be conducted in the Republic of Korea. A total of 80 subjects, aged 4 to 12 years, matched for age and sex, with body mass index at or above the 85th percentile or at or below the 25th percentile, will be included. Subjects will be assigned to the following 4 groups: obese/overweight with AD, normal/underweight with AD, obese/overweight control, and normal/underweight control. Serum metabolome and immune biomarkers, as well as fecal metabolome and microbiome biomarkers, will be analyzed. Serum eosinophil cationic protein, total serum Immunoglobulin E (IgE), and specific IgE will be analyzed to assess allergic tendency. The SCORing of AD index, the children's dermatology life quality index, body composition analysis, and the Korean gastrointestinal symptom rating scale will be obtained to assess the disease status and severity of the subjects.
The findings of this study are expected to provide evidence of an association between AD and obesity via a gut microbiome-metabolome-immune mechanism. Therefore, it may improve future management strategies for AD.
This study has been registered at the Korean National Clinical Trial Registry, Clinical Research Information Service (KCT0003630).
多项研究发现肥胖与特应性皮炎（AD）有关；然而，这种关联背后的机制在很大程度上尚不清楚。本研究旨在评估韩国人群中AD与肥胖的关联，并通过多组学分析验证其机制。
将在大韩民国进行一项病例对照研究。总共将纳入80名年龄在4至12岁之间、年龄和性别匹配、体重指数处于第85百分位数及以上或第25百分位数及以下的受试者。受试者将被分为以下4组：肥胖/超重合并AD组、正常/体重过轻合并AD组、肥胖/超重对照组和正常/体重过轻对照组。将分析血清代谢组和免疫生物标志物，以及粪便代谢组和微生物组生物标志物。将分析血清嗜酸性粒细胞阳离子蛋白、血清总免疫球蛋白E（IgE）和特异性IgE，以评估过敏倾向。将获取AD指数评分、儿童皮肤病生活质量指数、身体成分分析和韩国胃肠道症状评分量表，以评估受试者的疾病状态和严重程度。
本研究的结果有望通过肠道微生物组-代谢组-免疫机制提供AD与肥胖之间关联的证据。因此，它可能会改善未来AD的管理策略。
本研究已在韩国国家临床试验注册中心临床研究信息服务处注册（KCT0003630）。
