The relationship between incorporation of histamine and differentiation of neutrophil progenitors in murine bone marrow.

Histamine, at concentrations higher than 10(-8) M, promoted the differentiation of myeloblasts and promyelocytes of murine bone marrow. This effect was not inhibited by the presence of either pyrilamine or cimetidine. Incorporation was highly specific to histamine without being affected by various H1- and H2-agonists or antagonists, and seemed to be mediated by a specific transport system which includes new protein synthesis and is generated after the addition of 3H-histamine.