Institute of Biostructures and Bioimaging, IBB, CNR, Naples, Italy.
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy.
PLoS Pathog. 2022 Sep 1;18(9):e1010760. doi: 10.1371/journal.ppat.1010760. eCollection 2022 Sep.
The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.
人工智能（AI）在理解生物过程方面的影响可能是巨大的。阐明分枝杆菌的 PE_PGRS 结构对于揭示这些神秘蛋白质的作用至关重要。我们提出了一个 PGRS“航行”模型，作为一个智能工具，可以沿着菌膜扩散，暴露与宿主相互作用的结构基序，和/或在其 C 末端运输功能蛋白模块。
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