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PGRS 结构域：注定要在菌膜上航行。

PGRS domain structures: Doomed to sail the mycomembrane.

机构信息

Institute of Biostructures and Bioimaging, IBB, CNR, Naples, Italy.

Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy.

出版信息

PLoS Pathog. 2022 Sep 1;18(9):e1010760. doi: 10.1371/journal.ppat.1010760. eCollection 2022 Sep.

DOI:10.1371/journal.ppat.1010760
PMID:36048802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9436101/
Abstract

The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.

摘要

人工智能（AI）在理解生物过程方面的影响可能是巨大的。阐明分枝杆菌的 PE_PGRS 结构对于揭示这些神秘蛋白质的作用至关重要。我们提出了一个 PGRS“航行”模型，作为一个智能工具，可以沿着菌膜扩散，暴露与宿主相互作用的结构基序，和/或在其 C 末端运输功能蛋白模块。

相似文献

[1]
PGRS domain structures: Doomed to sail the mycomembrane.

PLoS Pathog. 2022-9

[2]
Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure.

Mol Microbiol. 2004-5

[3]
An overview to understand the role of PE_PGRS family proteins in Mycobacterium tuberculosis H37 Rv and their potential as new drug targets.

Biotechnol Appl Biochem. 2015

[4]
PGRS Domain of Rv0297 of Functions in A Calcium Dependent Manner.

Int J Mol Sci. 2021-8-30

[5]
Roles of PE_PGRS family in Mycobacterium tuberculosis pathogenesis and novel measures against tuberculosis.

Microb Pathog. 2010-7-16

[6]
PE_PGRS proteins of : A specialized molecular task force at the forefront of host-pathogen interaction.

Virulence. 2020-12

[7]
The PGRS Domain of Mycobacterium tuberculosis PE_PGRS Protein Rv0297 Is Involved in Endoplasmic Reticulum Stress-Mediated Apoptosis through Toll-Like Receptor 4.

mBio. 2018-6-19

[8]
The PGRS domain is responsible for translocation of PE_PGRS30 to cell poles while the PE and the C-terminal domains localize it to the cell wall.

FEBS Lett. 2014-2-11

[9]
PE_PGRS: Vital proteins in promoting mycobacterial survival and modulating host immunity and metabolism.

Cell Microbiol. 2021-3

[10]
Mycobacterial PE_PGRS proteins contain calcium-binding motifs with parallel beta-roll folds.

Genomics Proteomics Bioinformatics. 2007-12

引用本文的文献

[1]
Loss of the locus drives adaptive transcriptional responses and hypervirulence of lineage 2.

Sci Adv. 2025-7-4

[2]
The PE/PPE family proteins of : evolution, function, and prospects for tuberculosis control.

Front Immunol. 2025-6-17

[3]
Evolution of the PE_PGRS Proteins of Mycobacteria: Are All Equal or Are Some More Equal than Others?

Biology (Basel). 2025-2-28

[4]
Uncovering new families and folds in the natural protein universe.

Nature. 2023-10

[5]
Structural Basis of PE_PGRS Polymorphism, a Tool for Functional Modulation.

Biomolecules. 2023-5-10

[6]
Mycobacterial protein PE_PGRS30 induces macrophage apoptosis through prohibitin 2 mitochondrial function interference.

Front Microbiol. 2023-1-27

[7]
Molecular Immunology in Bacterial Vaccine Discovery.

Cells. 2022-11-28

本文引用的文献

[1]
Computational analysis and prediction of PE_PGRS proteins using machine learning.

Comput Struct Biotechnol J. 2022-1-22

[2]
The PE_PGRS Protein Family Acts as an Immunological Decoy to Subvert Host Immune Response.

Int J Mol Sci. 2022-1-4

[3]
AI revolutions in biology: The joys and perils of AlphaFold.

EMBO Rep. 2021-11-4

[4]
AlphaFold heralds a data-driven revolution in biology and medicine.

Nat Med. 2021-10

[5]
Highly accurate protein structure prediction with AlphaFold.

Nature. 2021-8

[6]
Type VII secretion systems: structure, functions and transport models.

Nat Rev Microbiol. 2021-9

[7]
Structure and dynamics of a mycobacterial type VII secretion system.

Nature. 2021-5

[8]
PE_PGRS3 ensures provision of the vital phospholipids cardiolipin and phosphatidylinositols by promoting the interaction between and host cells.

Virulence. 2021-12

[9]
PE_PGRS33, an Important Virulence Factor of and Potential Target of Host Humoral Immune Response.

Cells. 2021-1-15

[10]
PE_PGRS: Vital proteins in promoting mycobacterial survival and modulating host immunity and metabolism.

Cell Microbiol. 2021-3

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