Kwiecinski G G, Krook L, Wimsatt W A
Am J Anat. 1987 Apr;178(4):410-20. doi: 10.1002/aja.1001780410.
Studies of bone from summer-active little brown bats, Myotis lucifugus lucifugus, have demonstrated sex differences in the renewal of skeletal mineral reserves following spring-arousal from hibernation. Patterns of bone remodeling in both sexes of bats indicate that new bone formation does not occur during hibernation: All new bone formation occurs during the summer-active season. Results show that a short period of time elapses after hibernation before the initial demands of a large fetus and rapidly growing neonate are expressed on maternal skeletal reserves. Bone loss in summer-active females was associated with pregnancy and lactation, whereas summer-active males did not show evidence of bone loss but, instead, uninterrupted bone accretion throughout the summer-active season. Osteoclasts and bone-forming osteoblasts, absent during the hibernation period, reappeared on bone surfaces following spring-arousal from hibernation. There was no apparent increase in osteoclast numbers or activity during lactation but resorption cavities were found in deep cortical lamellae distant from bone surfaces. The increase in bone resorption in lactating bats appeared to be by osteocytic osteolysis, suggesting that it might be a significant mechanism of bone/calcium regulation in this hibernating mammal throughout the year.
对夏季活跃的北美小棕蝠（Myotis lucifugus lucifugus）骨骼的研究表明，在从冬眠中苏醒后的春季，骨骼矿物质储备更新存在性别差异。蝙蝠两性的骨骼重塑模式表明，冬眠期间不会发生新骨形成：所有新骨形成均发生在夏季活跃季节。结果显示，冬眠后经过一段短时间，大型胎儿和快速生长的新生儿的最初需求才会体现在母体骨骼储备上。夏季活跃的雌性蝙蝠的骨质流失与怀孕和哺乳有关，而夏季活跃的雄性蝙蝠没有骨质流失的迹象，相反，在整个夏季活跃季节骨骼持续增生。冬眠期间不存在的破骨细胞和成骨细胞，在从冬眠中苏醒后的春季重新出现在骨表面。哺乳期间破骨细胞数量或活性没有明显增加，但在远离骨表面的深层皮质骨板中发现了吸收腔。哺乳蝙蝠的骨吸收增加似乎是通过骨细胞性骨溶解实现的，这表明这可能是这种冬眠哺乳动物全年骨骼/钙调节的一个重要机制。
