Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany; Department of Interventional Biological Psychiatry, Freiburg University Medical Center, Freiburg, Germany.
Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany.
Int J Psychophysiol. 2022 Nov;181:40-49. doi: 10.1016/j.ijpsycho.2022.08.009. Epub 2022 Aug 29.
Subjective chronic tinnitus is a prevalent auditory perception characterized by an absence of a corresponding acoustic source. It is often accompanied by hearing deficits and may lead to various psychological problems including sleep disorder, depression and anxiety. To investigate the differential neuronal profile of patients with severe and less severe chronic tinnitus, 34 tinnitus patients were distributed in two groups and their EEG resting state activity was compared. Using standardized Low Resolution Electromagnetic Tomography (sLORETA) a significant and substantial frontal increase in theta wave activity was found in the group with severe tinnitus (p = .013). The correlated severity of depression and anxiety had no influence on the electrophysiological metric. These results support a tinnitus-related global network change in which prefrontal areas are part of a network which exerts a top-down influence on the auditory cortices. The demonstrated slowing of oscillations in the responsible network may constitute a neuronal marker for the prefrontal brain network lacking the capacity to inhibit overexcitation. The magnitude of this influence is linked to the subjective strength of the tinnitus distress.
主观慢性耳鸣是一种普遍存在的听觉感知现象，其特征是没有相应的声源。它常伴有听力损失，并可能导致各种心理问题，包括睡眠障碍、抑郁和焦虑。为了研究严重和轻度慢性耳鸣患者的神经元差异特征，将 34 名耳鸣患者分为两组，并比较其脑电图静息状态活动。使用标准化低分辨率电磁断层成像（sLORETA），发现严重耳鸣组的θ波活动在前额有显著而实质性的增加（p=0.013）。抑郁和焦虑的相关严重程度对电生理指标没有影响。这些结果支持与耳鸣相关的全局网络变化，其中前额叶区域是对听觉皮层施加自上而下影响的网络的一部分。在负责网络中观察到的振荡减慢可能构成前额叶脑网络缺乏抑制过度兴奋能力的神经元标记。这种影响的程度与耳鸣困扰的主观强度有关。
