Clinical Microbiologist, Microbiology Department, LabPlus, Auckland District Health Board, Auckland, New Zealand.
Bioinformatics Specialist, Microbiological Diagnostic Unit Public Health Laboratory, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
N Z Med J. 2022 Sep 2;135(1561):76-82. doi: 10.26635/6965.5783.
Carbapenem resistant Acinetobacter baumannii have limited treatment options and a propensity to cause hospital outbreaks. In recent years an increase in their detection has been observed in New Zealand. This study aimed to describe the molecular epidemiology of these isolates.
This study utilised carbapenem resistant A. baumannii complex isolates identified across New Zealand between January 2010 to April 2018. Whole genome sequence analysis and associated demographic information was used to contextualise local isolates within the global epidemiology and establish the relationship between isolates.
Thirty-three carbapenem resistant A. baumannii complex isolates (31 A. baumannii sensu stricto) were identified. Twenty-four (73%) were from January 2015 onwards. Twenty-four (73%) had an identifiable epidemiological link to overseas hospitalisation. Twenty-three (74%) of 31 A. baumannii sensu stricto were sequence type (ST) 2 (Pasteur scheme). Phylogenetic analysis identified three ST2 clusters. The largest cluster, of 12 isolates, was from 2015 onwards; with nine (75%) associated with recent hospitalisation in Fiji or Samoa.
Increasing numbers of carbapenem resistant A. baumannii are being identified in New Zealand. Our data show that this is in large part associated with transnational spread of a single A. baumannii sensu stricto ST 2 strain between Fiji, Samoa and New Zealand.
耐碳青霉烯鲍曼不动杆菌治疗选择有限，且容易引起医院感染爆发。近年来，新西兰检测到的耐碳青霉烯鲍曼不动杆菌数量有所增加。本研究旨在描述这些分离株的分子流行病学特征。
本研究利用 2010 年 1 月至 2018 年 4 月期间在新西兰各地发现的耐碳青霉烯鲍曼不动杆菌复合群分离株。通过全基因组序列分析和相关人口统计学信息，将当地分离株置于全球流行病学背景下，并确定分离株之间的关系。
共鉴定出 33 株耐碳青霉烯鲍曼不动杆菌复合群分离株（31 株鲍曼不动杆菌）。其中 24 株（73%）来自 2015 年 1 月以后。24 株（73%）与海外住院治疗有明确的流行病学联系。31 株鲍曼不动杆菌中有 23 株（74%）为 ST2 型（巴斯德方案）。系统发育分析确定了三个 ST2 聚类。最大的聚类有 12 个分离株，均来自 2015 年以后；其中 9 个（75%）与斐济或萨摩亚最近的住院治疗有关。
新西兰发现的耐碳青霉烯鲍曼不动杆菌数量不断增加。我们的数据表明，这在很大程度上与斐济、萨摩亚和新西兰之间单一的鲍曼不动杆菌 ST2 菌株的跨国传播有关。
