Lai K N, Leung J W, Vallance-Owen J
Am J Gastroenterol. 1987 Jul;82(7):665-8.
Six cirrhotic patients with intractable ascites had coexisting renal insufficiency. Dialytic ultrafiltration of ascitic fluid by hemofilter was attempted in these patients for symptomatic relief. The hemofilter removes fluid and substances with a molecular weight less than 50,000 daltons and the concentrated ascitic fluid was reinfused into the peritoneal cavity after ultrafiltration. A transient increase in urine output (p less than 0.01), urinary sodium excretion (p less than 0.01), and endogenous creatinine clearance (p less than 0.02) was noted and the plasma creatinine levels had remained stable for more than 4 months after the procedure. Our study suggests that dialytic ultrafiltration of ascites by hemofilter is a safe method in the management of patients with refractory ascites and renal insufficiency.
6例肝硬化顽固性腹水患者合并肾功能不全。尝试对这些患者采用血液滤过进行腹水透析超滤以缓解症状。血液滤过器可清除分子量小于50,000道尔顿的液体和物质，超滤后的浓缩腹水重新注入腹腔。结果发现尿量（p<0.01）、尿钠排泄（p<0.01）和内生肌酐清除率（p<0.02）短暂增加，且术后血浆肌酐水平在4个多月内保持稳定。我们的研究表明，血液滤过进行腹水透析超滤是治疗难治性腹水合并肾功能不全患者的一种安全方法。
