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桑椹狄尔斯-阿尔德型加合物：分离、结构、生物活性及合成

Mulberry Diels-Alder-type adducts: isolation, structure, bioactivity, and synthesis.

作者信息

Luo Si-Yuan, Zhu Jun-Yu, Zou Ming-Feng, Yin Sheng, Tang Gui-Hua

机构信息

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510006, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2022 Sep 2;12(1):31. doi: 10.1007/s13659-022-00355-y.

DOI:10.1007/s13659-022-00355-y
PMID:36050566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9436459/
Abstract

Mulberry Diels-Alder-type adducts (MDAAs) are unique phenolic natural products biosynthetically derived from the intermolecular [4 + 2]-cycloaddition of dienophiles (mainly chalcones) and dehydroprenylphenol dienes, which are exclusively distributed in moraceous plants. A total of 166 MDAAs with diverse skeletons have been isolated and identified since 1980. Structurally, the classic MDAAs characterized by the chalcone-skeleton dienophiles can be divided into eight groups (Types A - H), while others with non-chalcone dienophiles or some variations of classic MDAAs are non-classic MDAAs (Type I). These compounds have attracted significant attention of natural products and synthetic chemists due to their complex architectures, remarkable biological activities, and synthetic challenges. The present review provides a comprehensive summary of the structural properties, bioactivities, and syntheses of MDAAs. Cited references were collected between 1980 and 2021 from the SciFinder, Web of Science, and China National Knowledge Internet (CNKI).

摘要

桑科狄尔斯-阿尔德型加合物（MDAAs）是一类独特的酚类天然产物，通过亲双烯体（主要是查耳酮）与脱氢异戊二烯基酚二烯的分子间[4+2]环加成生物合成而来，它们仅分布于桑科植物中。自1980年以来，共分离鉴定出166种具有不同骨架的MDAAs。在结构上，以查耳酮骨架亲双烯体为特征的经典MDAAs可分为八组（A - H型），而其他具有非查耳酮亲双烯体或经典MDAAs某些变体的则为非经典MDAAs（I型）。由于其复杂的结构、显著的生物活性和合成挑战，这些化合物引起了天然产物和合成化学家的极大关注。本综述对MDAAs的结构性质、生物活性和合成进行了全面总结。引用的参考文献于1980年至2021年间从SciFinder、科学网和中国知网（CNKI）收集。

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