Pant Reproductive Biology, Genetic Diversity and Phytochemistry Research Laboratory, Department of Botany, University of Kashmir, Srinagar, 190006, India.
Plant Tissue Culture and Research Laboratory, Department of Botany, University of Kashmir, Srinagar, 190006, India.
Environ Monit Assess. 2024 Feb 7;196(3):241. doi: 10.1007/s10661-024-12338-2.
Phytochemicals are broadly acknowledged for their health-promoting effects owing to the fact of their capacity to counteract free radicals (e.g., superoxide anion radical, hydroxyl radical, hydroperoxyl radical, singlet oxygen, hypochlorite, and nitric oxide) and shield against oxidative stress induced by environmental factors. This study aimed to investigate the relationship between altitude, morphology, soil parameters, in vitro antioxidant potential and phytochemical composition of Phlomis cashmeriana collected from four different locations of Kashmir Himalaya characterized by diverse habitats and elevations. Various factors, such as extraction method, solvent polarity, and habitat conditions, can impact the quantity and efficacy of phytochemicals in plants. The aim of current study was to analyze phytochemical composition and antioxidant activity of P. cashmeriana, an important medicinal plant found in the Kashmir Himalaya region. The antioxidant activity was accessed using several assays and the plant populations were selected based on their diverse habitat features and altitudes. HR-LCMS was conducted for both below-ground and above-ground parts. Some important compounds such as, catechin, vinainsenoside, acutilobin, and kaempferol were reported for the first time from P. cashmeriana. Results showed that methanol was the most efficient solvent for extracting phytochemicals. During the current study, it was also found that the below-ground parts exhibited superior antioxidant activity compared to the above-ground parts. Notably, Site IV demonstrated the highest antioxidant potential; a positive correlation between altitude and antioxidant activity was also found. In conclusion, present research identified specific elite populations having highest antioxidant potential and are well-suited for large-scale cultivation of P. cashmeriana.
植物化学物质因其能够中和自由基（如超氧阴离子自由基、羟基自由基、过氧自由基、单线态氧、次氯酸盐和一氧化氮）并抵御环境因素引起的氧化应激的能力而被广泛认为具有促进健康的作用。本研究旨在探讨不同海拔、形态、土壤参数、体外抗氧化潜力以及在克什米尔喜马拉雅地区四个不同地点采集的宽叶缬草的植物化学成分之间的关系，这些地点的生境和海拔不同。提取方法、溶剂极性和生境条件等各种因素都可能影响植物中植物化学物质的数量和功效。本研究旨在分析克什米尔喜马拉雅地区重要药用植物宽叶缬草的植物化学成分和抗氧化活性。使用几种测定法评估了抗氧化活性，并根据其不同的生境特征和海拔选择了植物种群。对地下和地上部分进行了 HR-LCMS 分析。首次从宽叶缬草中报道了一些重要化合物，如儿茶素、vinainsenoside、acutilobin 和山奈酚。结果表明，甲醇是提取植物化学物质最有效的溶剂。在本研究中，还发现地下部分的抗氧化活性优于地上部分。特别是，站点 IV 表现出最高的抗氧化潜力；还发现了海拔与抗氧化活性之间的正相关关系。总之，本研究确定了具有最高抗氧化潜力的特定精英种群，非常适合大规模种植宽叶缬草。
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