Katsanis E, Hsu E, Luke K H, McKee J A
Am J Hematol. 1987 Jun;25(2):211-4. doi: 10.1002/ajh.2830250211.
Two adolescent black females with sickle cell disease who developed systemic lupus erythematosus (SLE) are presented. The recognition of SLE was delayed because all new symptoms were initially attributed to their underlying sickle cell disease. Nine similar cases have been previously reported. The hypothesis that a deficiency of the alternative complement pathway in some patients with sickle hemoglobinopathies predisposes them toward immune complex disorders was not confirmed in our study. Our first patient had normal and our second increased activity of the alternative pathway of complement activation.
本文介绍了两名患有镰状细胞病并发展为系统性红斑狼疮（SLE）的青春期黑人女性。SLE的诊断被延迟，因为所有新出现的症状最初都被归因于其潜在的镰状细胞病。此前已有9例类似病例的报道。我们的研究未证实镰状血红蛋白病患者中替代补体途径缺陷使他们易患免疫复合物疾病这一假说。我们的第一位患者补体激活替代途径活性正常，第二位患者该活性升高。
