Eissa M M, Lawrence J M, McKenzie L, Little F M, Mankad V N, Yang Y M
Department of Pediatrics, University of South Alabama, Mobile 36617, USA.
South Med J. 1995 Nov;88(11):1176-8. doi: 10.1097/00007611-199511000-00023.
Although sickle cell disease (SCD) and systemic lupus erythematosus (SLE) are two distinct chronic diseases, many clinical features are common to both conditions. We describe a young patient who had a mild clinical course of SCD until SLE developed when he was 15 years old. His initial manifestations of SLE including fever, chest pain, and lung infiltration with pleural effusion were thought to be complications of SCD. However, a deteriorating clinical course, presence of facial and truncal rash, and persistent pleural effusion led to the diagnosis of SLE. We compare our case and the 10 previously reported cases and discuss the possible association of complement defects and the pathogenesis of SLE in patients with SCD. Our report illustrates the importance of considering other disease processes when clinical features are atypical of SCD.
尽管镰状细胞病（SCD）和系统性红斑狼疮（SLE）是两种不同的慢性疾病，但许多临床特征在这两种疾病中都很常见。我们描述了一名年轻患者，他在15岁患SLE之前SCD的临床病程较轻。他SLE的初始表现包括发热、胸痛和伴有胸腔积液的肺部浸润，最初被认为是SCD的并发症。然而，临床病程的恶化、面部和躯干皮疹的出现以及持续的胸腔积液导致了SLE的诊断。我们将我们的病例与之前报道的10例病例进行了比较，并讨论了补体缺陷与SCD患者SLE发病机制之间可能的关联。我们的报告说明了当临床特征不符合SCD的典型表现时，考虑其他疾病过程的重要性。
