Wu Pei-Yu, Tan Xianzu, Wang Min, Zheng Xiangqing, Lou Jin-He
Department of VIP, Chongqing General Hospital, Chongqing, China.
Department of Health Management Center, Chongqing General Hospital, Chongqing, China.
Gynecol Endocrinol. 2022 Nov;38(11):928-934. doi: 10.1080/09513590.2022.2118709. Epub 2022 Sep 1.
The efficacy of selenium supplementation was elusive for polycystic ovary syndrome. This meta-analysis aimed to explore the efficacy of selenium supplementation for polycystic ovary syndrome. PubMed, EMbase, Web of science, EBSCO, Cochrane library database, CNKI, Chongqing VIP database and Wanfang databases have been searched through July 2022 and we included randomized controlled trials (RCTs) reporting the effect of selenium supplementation versus placebo in patients with polycystic ovary syndrome. Five RCTs were included in the meta-analysis. Compared with placebo group for polycystic ovary syndrome, selenium supplementation was associated with significantly reduced total testosterone (SMD=-0.42; 95% CI=-0.78 to -0.06; = 0.02) and cholesterol (SMD=-0.71; 95% CI=-1.41 to -0.02; = 0.04), but revealed no remarkable influence on SHBG (SMD=-0.52; 95% CI=-1.29 to 0.25; = 0.19), triglyceride (SMD=-1.45; 95% CI=-3.62 to 0.73; = 0.19), LDL (SMD=-0.17; 95% CI=-0.72 to 0.37; = 0.53), FPG (SMD=-0.95; 95% CI=-3.72 to 1.82; = 0.50) or HOMA-IR (SMD=-0.51; 95% CI=-3.79 to 2.77; = 0.76). Selenium supplementation may be able to improve the metabolic response for polycystic ovary syndrome, and this finding should be interpreted with caution.
补充硒对多囊卵巢综合征的疗效尚不明确。本荟萃分析旨在探讨补充硒对多囊卵巢综合征的疗效。截至2022年7月，我们检索了PubMed、EMbase、Web of science、EBSCO、Cochrane图书馆数据库、中国知网、重庆维普数据库和万方数据库，纳入了报告补充硒与安慰剂对多囊卵巢综合征患者疗效对比的随机对照试验（RCT）。荟萃分析纳入了5项RCT。与多囊卵巢综合征的安慰剂组相比，补充硒与总睾酮显著降低（标准化均数差[SMD]=-0.42；95%置信区间[CI]=-0.78至-0.06；P=0.02）和胆固醇显著降低（SMD=-0.71；95%CI=-1.41至-0.02；P=0.04）相关，但对性激素结合球蛋白（SHBG）（SMD=-0.52；95%CI=-1.29至0.25；P=0.19）、甘油三酯（SMD=-1.45；95%CI=-3.62至0.73；P=0.19）、低密度脂蛋白（LDL）（SMD=-0.17；95%CI=-0.72至0.37；P=0.53）、空腹血糖（FPG）（SMD=-0.95；95%CI=-3.72至1.82；P=0.50）或胰岛素抵抗指数（HOMA-IR）（SMD=-0.51；95%CI=-3.79至2.77；P=0.76）无显著影响。补充硒可能能够改善多囊卵巢综合征的代谢反应，这一发现应谨慎解读。
