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硒补充剂对多囊卵巢综合征的影响：基于随机临床试验的系统评价和荟萃分析。

Effects of selenium supplementation on Polycystic Ovarian Syndrome: a systematic review and meta-analysis on randomized clinical trials.

机构信息

Shandong University of Traditional Chinese Medicine, 16369 Jingshi Road, Lixia District, Jinan, 250011, Shandong, China.

Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China.

出版信息

BMC Endocr Disord. 2023 Feb 6;23(1):33. doi: 10.1186/s12902-023-01286-6.

DOI:10.1186/s12902-023-01286-6
PMID:36740666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9901141/
Abstract

BACKGROUND

This study provides a systematic review and meta-analysis of randomized controlled trials, which examined the effect of the selenium supplementation on polycystic ovary syndrome (PCOS).

METHODS

Confirmed studies related to selenium supplementation and PCOS were searched from the databases of EMBASE, PubMed and Web of Science. Data were reported as weighted mean difference (WMD) or standard mean difference (SMD) and associated 95% confidence intervals (CIs). Analysis was performed with Stata version 12.0.

RESULTS

A total of 389 cases (selenium group n = 195, control group n = 194) were included in this studies. This meta-analysis showed that selenium supplementation has a positive effect on TAC, and supplementation of selenium does not significantly improve the level of BMI, Weight, LDL, HDL, Triglycerides, Total Testosterone, HOMA-IR, NO, GSH, MDA and FPG.

CONCLUSION

Although selenium can improve TAC in PCOS patients, it has no significant effect on BMI, Total Testosterone, et al. In terms of the results of this meta-analysis, it is not recommended for patients with PCOS to use selenium as a regular trace element supplement. Based on the improving effect of selenium on TAC, supplementation of selenium may have a positive effect on improving follicle quality for some PCOS patients who have poor follicle quality caused by oxidative stress or who want to undergo IVF.

摘要

背景

本研究对随机对照试验进行了系统评价和荟萃分析，旨在探讨补充硒对多囊卵巢综合征（PCOS）的影响。

方法

从 EMBASE、PubMed 和 Web of Science 数据库中检索与硒补充和 PCOS 相关的确定研究。数据以加权均数差（WMD）或标准均数差（SMD）和相关 95%置信区间（CI）报告。使用 Stata 版本 12.0 进行分析。

结果

共有 389 例（硒组 n=195，对照组 n=194）纳入本研究。荟萃分析表明，硒补充对 TAC 有积极影响，补充硒并不能显著改善 BMI、体重、LDL、HDL、甘油三酯、总睾酮、HOMA-IR、NO、GSH、MDA 和 FPG 的水平。

结论

虽然硒可以改善 PCOS 患者的 TAC，但对 BMI、总睾酮等没有显著影响。基于本荟萃分析的结果，不建议 PCOS 患者将硒作为常规微量元素补充剂。鉴于硒对 TAC 的改善作用，对于因氧化应激导致卵泡质量较差或希望进行 IVF 的某些 PCOS 患者，补充硒可能对改善卵泡质量有积极作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/67e42af8eed7/12902_2023_1286_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/51a68577588d/12902_2023_1286_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/d7ac18828b4a/12902_2023_1286_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/be6c8978e0cc/12902_2023_1286_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/eb724fe2d8cb/12902_2023_1286_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/7bcd9b8dc31f/12902_2023_1286_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/4864fa44376a/12902_2023_1286_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/edc128b0b30f/12902_2023_1286_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/67e42af8eed7/12902_2023_1286_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/51a68577588d/12902_2023_1286_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/d7ac18828b4a/12902_2023_1286_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/be6c8978e0cc/12902_2023_1286_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/eb724fe2d8cb/12902_2023_1286_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/7bcd9b8dc31f/12902_2023_1286_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/4864fa44376a/12902_2023_1286_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/edc128b0b30f/12902_2023_1286_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500e/9901141/67e42af8eed7/12902_2023_1286_Fig8_HTML.jpg

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2
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J Steroid Biochem Mol Biol. 2020 Apr;198:105570. doi: 10.1016/j.jsbmb.2019.105570. Epub 2019 Dec 26.
3
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4
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Front Immunol. 2024 Dec 19;15:1470283. doi: 10.3389/fimmu.2024.1470283. eCollection 2024.
5
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6
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