探索淀粉样β蛋白水平低而新皮质tau蛋白正电子发射断层扫描水平高的不一致病例。
Exploring discordant low amyloid beta and high neocortical tau positron emission tomography cases.
作者信息
Krishnadas Natasha, Doré Vincent, Laws Simon M, Porter Tenielle, Lamb Fiona, Bozinovski Svetlana, Villemagne Victor L, Rowe Christopher C
机构信息
Florey Department of Neurosciences & Mental Health The University of Melbourne Parkville Victoria Australia.
Department of Molecular Imaging & Therapy Austin Health Heidelberg Victoria Australia.
出版信息
Alzheimers Dement (Amst). 2022 Aug 26;14(1):e12326. doi: 10.1002/dad2.12326. eCollection 2022.
INTRODUCTION
Neocortical 3R4R (3-repeat/4-repeat) tau aggregates are rarely observed in the absence of amyloid beta (Aβ). F-MK6240 binds specifically to the 3R4R form of tau that is characteristic of Alzheimer's disease (AD). We report four cases with negative Aβ, but positive tau positron emission tomography (PET) findings.
METHODS
All Australian Imaging, Biomarkers and Lifestyle study of aging (AIBL) study participants with Aβ (F-NAV4694) and tau (F-MK6240) PET scans were included. Centiloid <25 defined negative Aβ PET (Aβ-). The presence of neocortical tau was defined quantitatively and visually.
RESULTS
Aβ- PET was observed in 276 participants. Four of these participants (one cognitively unimpaired [CU], two mild cognitive impairment [MCI], one AD) had tau tracer retention in a pattern consistent with Braak tau stages V to VI. Fluid biomarkers supported a diagnosis of AD. In silico analysis of , and genes did not identify relevant functional mutations.
DISCUSSION
Discordant cases were infrequent (1.4% of all Aβ- participants). In these cases, the Aβ PET ligand may not be detecting the Aβ that is present.
引言
在没有淀粉样β（Aβ）的情况下，很少观察到新皮质3R4R（3重复/4重复）tau蛋白聚集。F-MK6240特异性结合阿尔茨海默病（AD）特有的3R4R形式的tau蛋白。我们报告了4例Aβ阴性但tau正电子发射断层扫描（PET）结果为阳性的病例。
方法
纳入所有参加澳大利亚成像、生物标志物和衰老生活方式研究（AIBL）且进行了Aβ（F-NAV4694）和tau（F-MK6240）PET扫描的参与者。Centiloid<25定义为Aβ PET阴性（Aβ-）。通过定量和视觉方式定义新皮质tau蛋白的存在。
结果
276名参与者观察到Aβ- PET。其中4名参与者（1名认知未受损[CU]，2名轻度认知障碍[MCI]，1名AD）的tau示踪剂滞留模式与Braak tau分期V至VI一致。血液生物标志物支持AD的诊断。对 、 和 基因的计算机分析未发现相关功能突变。
讨论
不一致的病例很少见（占所有Aβ-参与者的1.4%）。在这些病例中，Aβ PET配体可能未检测到存在的Aβ。
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