癌症中CD8 T细胞干性和耗竭的性别偏见。
Sex-bias in CD8 T-cell stemness and exhaustion in cancer.
作者信息
Hussain Tabinda, Kallies Axel, Vasanthakumar Ajithkumar
机构信息
Olivia Newton-John Cancer Research Institute Heidelberg VIC Australia.
La Trobe University Bundoora VIC Australia.
出版信息
Clin Transl Immunology. 2022 Aug 26;11(8):e1414. doi: 10.1002/cti2.1414. eCollection 2022.
Abstract
This commentary article highlights two recently published studies, which for the first time revealed the immunological underpinnings of sex-bias in cancer incidence and mortality. These studies showed that the androgen receptor restrains anti-tumour immunity in males by repressing cytotoxic genes in CD8 T cells.
摘要
这篇评论文章重点介绍了最近发表的两项研究，这两项研究首次揭示了癌症发病率和死亡率中性别偏见的免疫学基础。这些研究表明，雄激素受体通过抑制CD8 T细胞中的细胞毒性基因来抑制男性的抗肿瘤免疫。
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