CD40、CD86 和谷胱甘肽 S-转移酶 Omega 1 在慢性阻塞性肺疾病发病机制中的作用。
The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
机构信息
Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
出版信息
Can Respir J. 2022 Aug 23;2022:6810745. doi: 10.1155/2022/6810745. eCollection 2022.
OBJECTIVE
The aim of the study was to explore the relevance of CD40, CD86, and GSTO1 with the pathogenesis of COPD.
METHODS
Patients with acute exacerbation of COPD were contrasted with the healthy and nonsmoking ones and smoking but without COPD ones. The changes of CD40, CD86, and GSTO1 in the peripheral blood, collected from different groups, were detected by flow cytometry and western blotting, respectively.
RESULTS
Compared with the nonsmoking group and smoking but without the COPD group, the expression of CD40 and CD86 of the patients with COPD increased significantly, but the expression of GSTO1 decreased. CD40 and CD86 were negatively correlated with FEV1%, while GSTO1 was positively correlated with FEV1% and negatively correlated with CD40 and CD86.
CONCLUSION
CD40, CD86, and GSTO1 may play a role in the pathogenesis of COPD, and they are related to the severity of COPD and the degree of changes in the lung function.
目的
本研究旨在探讨 CD40、CD86 和 GSTO1 与 COPD 发病机制的相关性。
方法
将 COPD 急性加重期患者与健康非吸烟人群和吸烟但无 COPD 人群进行对比。分别采用流式细胞术和 Western blot 法检测不同组别患者外周血中 CD40、CD86 和 GSTO1 的变化。
结果
与非吸烟组和吸烟但无 COPD 组相比，COPD 患者的 CD40 和 CD86 表达明显增加，而 GSTO1 表达降低。CD40 和 CD86 与 FEV1%呈负相关，而 GSTO1 与 FEV1%呈正相关，与 CD40 和 CD86 呈负相关。
结论
CD40、CD86 和 GSTO1 可能在 COPD 的发病机制中发挥作用，与 COPD 的严重程度和肺功能变化程度有关。
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