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从菌株KIB-H1544中分离并生物合成曼陀罗霉素。

Isolation and biosynthesis of daturamycins from sp. KIB-H1544.

作者信息

Chen Yin, Ren Jinqiu, Yang Ruimin, Li Jie, Huang Sheng-Xiong, Yan Yijun

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

University of Chinese Academy of Sciences, Beijing 100049, China.

出版信息

Beilstein J Org Chem. 2022 Aug 9;18:1009-1016. doi: 10.3762/bjoc.18.101. eCollection 2022.

DOI:10.3762/bjoc.18.101
PMID:36051563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9379647/
Abstract

Two novel diarylcyclopentenones daturamycin A and B ( and ), and one new -terphenyl daturamycin C (), along with three known congeners (-), were isolated from a rhizosphere soil-derived sp. KIB-H1544. The structures of new compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Compounds and belong to a rare class of tricyclic 6/5/6 diarylcyclopentenones, and compounds - possess a C-18 tricyclic aromatic skeleton. The biosynthetic gene cluster of daturamycins was identified through gene knockout and biochemical characterization experiments and the biosynthetic pathway of daturamycins was proposed.

摘要

从根际土壤来源的链霉菌属菌株KIB-H1544中分离出两种新型二芳基环戊烯酮类化合物曼陀罗霉素A和B（以及），一种新型三联苯类化合物曼陀罗霉素C（），以及三种已知同系物（-）。通过光谱分析和单晶X射线衍射联用确定了新化合物的结构。化合物和属于一类罕见的三环6/5/6二芳基环戊烯酮，化合物-具有C-18三环芳香骨架。通过基因敲除和生化表征实验鉴定了曼陀罗霉素的生物合成基因簇，并提出了曼陀罗霉素的生物合成途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9379647/1ffd1ce12415/Beilstein_J_Org_Chem-18-1009-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9379647/c9086857692b/Beilstein_J_Org_Chem-18-1009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9379647/22bdafcbbc8b/Beilstein_J_Org_Chem-18-1009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9379647/d043ebd575aa/Beilstein_J_Org_Chem-18-1009-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9379647/1ffd1ce12415/Beilstein_J_Org_Chem-18-1009-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9379647/c9086857692b/Beilstein_J_Org_Chem-18-1009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9379647/22bdafcbbc8b/Beilstein_J_Org_Chem-18-1009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9379647/d043ebd575aa/Beilstein_J_Org_Chem-18-1009-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9379647/1ffd1ce12415/Beilstein_J_Org_Chem-18-1009-g005.jpg

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