State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.
University of the Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
J Nat Prod. 2020 Jan 24;83(1):111-117. doi: 10.1021/acs.jnatprod.9b00903. Epub 2020 Jan 6.
Seven new trialkyl-substituted benzene derivatives named benwamycins A-G (-), together with three known congeners, -, were isolated from culture broth of the soil-derived sp. KIB-H1471. Their structures were elucidated by using 1D and 2D NMR analyses in combination with HRESIMS data. The absolute configurations of - were determined by chemical conversion and comparison of circular dichroism spectra and confirmed for by single-crystal X-ray crystallography. Compounds and have a unique γ-pyrone-like ring on one side chain. Compounds and inhibited human T cell proliferation with IC values of 14.3 and 12.5 μM, respectively, without obvious cytotoxicity for naïve human T cells. Compounds and could weakly enhance insulin-stimulated glucose uptake.
从土壤来源的 sp. KIB-H1471 的发酵液中分离得到了 7 种新的三烷基取代苯衍生物，命名为 benwamycins A-G(-)，以及 3 种已知同系物 、、。通过 1D 和 2D NMR 分析结合 HRESIMS 数据，确定了它们的结构。通过化学转化和比较圆二色谱光谱，并通过单晶 X 射线晶体学确定了 、、的绝对构型。化合物 、、在一侧链上具有独特的γ-吡喃酮样环。化合物 、、对人 T 细胞增殖的抑制作用分别为 14.3 和 12.5 μM，对幼稚人 T 细胞没有明显的细胞毒性。化合物 、、可以弱增强胰岛素刺激的葡萄糖摄取。
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