Barnes Kay B, Richards Mark I, Burgess Gary, Armstrong Stuart J, Bentley Christine, Maishman Thomas C, Laws Thomas R, Nelson Michelle, Harding Sarah V
Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom.
MerLion Pharmaceuticals, Berlin, Germany.
Front Microbiol. 2022 Aug 16;13:934312. doi: 10.3389/fmicb.2022.934312. eCollection 2022.
The efficacy of finafloxacin as a component of a layered defense treatment regimen was determined and against an infection with . Doxycycline was down-selected from a panel of antibiotics evaluated and used in combination with finafloxacin in a Balb/c mouse model of inhalational melioidosis. When treatment was initiated at 24 h post-infection with , there were no differences in the level of protection offered by finafloxacin or doxycycline (as monotherapies) when compared to the combination therapy. There was evidence for improved bacterial control in the groups treated with finafloxacin (as monotherapies or in combination with doxycycline) when compared to mice treated with doxycycline. Survival comparisons of finafloxacin and doxycycline (as monotherapies) or in combination initiated at 36 h post-infection indicated that finafloxacin was superior to doxycycline. Doxycycline was also unable to control the levels of bacteria within tissues to the extent that doxycycline and finafloxacin used in combination or finafloxacin (as a sole therapy) could. In summary, finafloxacin is a promising therapy for use in the event of exposure to
测定了非那沙星作为分层防御治疗方案的一种成分对……感染的疗效。强力霉素是从一组评估过的抗生素中筛选出来的，并在吸入性类鼻疽Balb/c小鼠模型中与非那沙星联合使用。在感染……后24小时开始治疗时，与联合治疗相比，非那沙星或强力霉素（作为单一疗法）提供的保护水平没有差异。与用强力霉素治疗的小鼠相比，有证据表明在用非那沙星治疗的组（作为单一疗法或与强力霉素联合使用）中细菌控制得到改善。在感染后36小时开始的非那沙星和强力霉素（作为单一疗法）或联合使用的生存比较表明，非那沙星优于强力霉素。强力霉素也无法像联合使用强力霉素和非那沙星或非那沙星（作为单一疗法）那样控制组织内的细菌水平。总之，非那沙星是一种在暴露于……情况下有前景的治疗方法
