用于评估雾化感染治疗方法的BALB/c小鼠模型
The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized .
作者信息
Nelson Michelle, Barnes Kay B, Davies Carwyn H, Cote Christopher K, Meinig J Matthew, Biryukov Sergei S, Dyer David N, Frick Ondraya, Heine Henry, Pfefferle Denise A, Horstman-Smith Amanda, Barbaras Julie, Harding Sarah V
机构信息
Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.
United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
出版信息
Antibiotics (Basel). 2023 Mar 3;12(3):506. doi: 10.3390/antibiotics12030506.
Abstract
, the causative agent of the disease melioidosis, has been isolated from the environment in 45 countries. The treatment of melioidosis is complex, requiring lengthy antibiotic regimens, which can result in the relapse of the disease following treatment cessation. It is important that novel therapies to treat infections with be assessed in appropriate animal models, and discussions regarding the different protocols used between laboratories are critical. A 'deep dive' was held in October 2020 focusing on the use of the BALB/c mouse model and the inhalational route of infection to evaluate new antibiotic therapies.
摘要
类鼻疽病的病原体已在45个国家的环境中被分离出来。类鼻疽病的治疗很复杂，需要长期的抗生素治疗方案，这可能导致治疗停止后疾病复发。在适当的动物模型中评估治疗感染的新疗法很重要，并且关于实验室之间使用的不同方案的讨论至关重要。2020年10月举行了一次“深入探讨”，重点是使用BALB/c小鼠模型和吸入感染途径来评估新的抗生素疗法。
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