Pan Fan, Lin Xinrong, Hao Liping, Wang Ting, Song Haizhu, Wang Rui
Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Front Cell Dev Biol. 2022 Jun 21;10:882571. doi: 10.3389/fcell.2022.882571. eCollection 2022.
Liver cancer is the sixth most frequently diagnosed cancer and the third dominant cause of cancer death worldwide. Ferroptosis is characterized as an iron-dependent form of regulated cell death, with accumulation of lipid peroxides to lethal amounts. Evidences have showed that ferroptosis is closely associated with HCC, but the mechanisms are still poorly understood. In this review, we mainly summarize the roles of several typical molecules as well as radiotherapy in regulating the ferroptosis process in HCC. Chances are that this review may help address specific issues in the treatment of HCC.
肝癌是全球第六大最常被诊断出的癌症，也是癌症死亡的第三大主要原因。铁死亡是一种铁依赖性的程序性细胞死亡形式，其特征是脂质过氧化物积累到致死量。有证据表明，铁死亡与肝癌密切相关，但其机制仍知之甚少。在这篇综述中，我们主要总结了几种典型分子以及放疗在调节肝癌铁死亡过程中的作用。这篇综述可能有助于解决肝癌治疗中的具体问题。
