Lobel S A, Abeyounis C J, Milgrom F
Transplantation. 1978 Oct;26(4):239-44. doi: 10.1097/00007890-197810000-00007.
Evidence is presented that skin-reacting transplantation antibodies (SRTA) can be elicited not only by skin allografts, but also by injection of dispersed allogeneic lymphoid cells. Two mechanisms of action of SRTA, which are not mutually exclusive, are compatible with the experimental results. (1) SRTA may act as homocytotropic antibodies, producing skin reactions by fixing to the skin of the test animal and combining with circulating antigens brought to the test site. (2) SRTA may produce skin reactions by combining directly with "sessile" antigens in the skin. Genetic studies showed that the antigens combining with SRTA are inherited as simple Mendelian traits. Furthermore, it was shown that these antigens are not related to the major rat histocompatibility antigens, Ag-B, nor are they related to any other described rat alloantigen system. Thus, the antigens responsible for SRTA belong to a new antigenic system.
有证据表明，不仅同种异体皮肤移植可引发皮肤反应性移植抗体（SRTA），注射分散的同种异体淋巴细胞也可引发。SRTA的两种作用机制并非相互排斥，与实验结果相符。（1）SRTA可能作为亲同种细胞抗体，通过固定在试验动物的皮肤上并与带到试验部位的循环抗原结合而产生皮肤反应。（2）SRTA可能通过直接与皮肤中的“固定”抗原结合而产生皮肤反应。遗传学研究表明，与SRTA结合的抗原作为简单的孟德尔性状遗传。此外，研究表明这些抗原与大鼠主要组织相容性抗原Ag-B无关，也与任何其他已描述的大鼠同种异体抗原系统无关。因此，负责SRTA的抗原属于一个新的抗原系统。
