Miller K W, Keith J C
Department of Veterinary Biosciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg.
Am J Obstet Gynecol. 1988 Nov;159(5):1241-6. doi: 10.1016/0002-9378(88)90457-7.
Erythrocyte morphologic characteristics and serum chemistry results were studied in 10 gravid ewes during experimental ovine pregnancy-induced hypertension and subsequent administration of the thromboxane synthetase inhibitors CGS13080 and CGS12970. During the hypertensive period mean arterial blood pressure, plasma thromboxane B2 levels, and serum chemistry results, and electrolyte levels were significantly altered. Parameters returned to baseline values or were improved after drug administration. Erythrocyte morphologic features did not change significantly with the onset of the syndrome. Echinocytosis was present during baseline measurement and persisted throughout hypertension. However, after thromboxane synthetase inhibition, percentages of discocytes increased (p less than or equal to 0.005) with the same frequency that echinocyte numbers decreased (p less than or equal to 0.05). Schistocytes were present throughout the study, and changes in their numbers were not detected. Serum phosphorus, blood urea nitrogen, and bilirubin levels and anion gap rose significantly during hypertension and returned to normal levels after drug treatment. We speculate that CGS13080 or CGS12970, by decreasing thromboxane levels and blood pressure, promoted the normalization of erythrocyte membranes.
在10只妊娠母羊实验性诱发妊娠高血压及随后给予血栓素合成酶抑制剂CGS13080和CGS12970的过程中，对红细胞形态学特征和血清化学结果进行了研究。在高血压期，平均动脉血压、血浆血栓素B2水平、血清化学结果及电解质水平均发生显著改变。给药后各项参数恢复至基线值或有所改善。红细胞形态学特征并未随综合征的发生而显著改变。在基线测量时存在棘形红细胞增多，且在整个高血压期持续存在。然而，在抑制血栓素合成酶后，双凹圆盘形红细胞的百分比增加（p≤0.005），同时棘形红细胞数量减少（p≤0.05），且两者出现频率相同。在整个研究过程中均存在裂红细胞，但其数量变化未被检测到。高血压期间血清磷、血尿素氮、胆红素水平及阴离子间隙显著升高，药物治疗后恢复至正常水平。我们推测，CGS13080或CGS12970通过降低血栓素水平和血压，促进了红细胞膜的正常化。
