Minai Lisa, Takeichi Takuya, Ogawa Youichi, Honobe-Tabuchi Akiko, Okamoto Takashi, Mitsui Hiroshi, Shimada Shinji, Akiyama Masashi, Kawamura Tatsuyoshi
Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
J Dermatol. 2023 Feb;50(2):245-249. doi: 10.1111/1346-8138.16563. Epub 2022 Sep 2.
In dermatology, biologics that block signaling pathways of TNF-α, IL-4/IL13, IL-17s, and IL-23 are widely used for the treatment of several inflammatory skin diseases, such as atopic dermatitis and psoriasis. They have shown excellent efficacy with an acceptable safety profile. However, these biologics targeting pathogenic cytokines and their receptors could modulate immunological balance, leading to the development of other inflammatory or autoimmune skin diseases in some cases. In this study, we present a patient who suffered pemphigus vegetans and showed an exacerbation of pemphigus foliaceus after secukinumab loading for the treatment of complicated generalized pustular psoriasis and pyoderma gangrenosum.
在皮肤科，阻断肿瘤坏死因子-α、白细胞介素-4/白细胞介素-13、白细胞介素-17和白细胞介素-23信号通路的生物制剂被广泛用于治疗多种炎症性皮肤病，如特应性皮炎和银屑病。它们已显示出优异的疗效且安全性可接受。然而，这些靶向致病性细胞因子及其受体的生物制剂可能会调节免疫平衡，在某些情况下导致其他炎症性或自身免疫性皮肤病的发生。在本研究中，我们报告了一名患有增殖性天疱疮的患者，在使用司库奇尤单抗治疗复杂性泛发性脓疱型银屑病和坏疽性脓皮病后，出现了落叶型天疱疮的加重。
