Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.
J Oral Pathol Med. 2012 Sep;41(8):584-8. doi: 10.1111/j.1600-0714.2012.01152.x. Epub 2012 May 5.
Pyostomatitis vegetans (PSV) is an intraoral pustular eruption considered by most authors to represent the mucous analogous of cutaneous pyoderma gangrenosum and its vegetating presentations (pyodermatitis vegetans). A strong correlation of PSV with inflammatory bowel disease (IBD) is well documented. The histopathology of PSV lesions usually reveals acanthosis, and neutrophils and/or eosinophils infiltration with intraepithelial or subepithelial abscesses; acantholysis is present in some cases. We studied four patients with IBD that presented oral lesions suggestive of PSV. Two male and two female patients were included. The histopathology of oral lesions of two patients revealed findings typical for PSV. The other two patients showed findings typical for pemphigus vulgaris (PV), although the course of their symptoms paralleled that of the bowel disease. Our findings may suggest that pustular lesions in patients with IBD can be a presentation of both PSV and PV; adequate diagnosis is required because clinical presentation is very similar.
脓疱性口炎（PSV）是一种口腔脓疱性发作，大多数作者认为它代表了皮肤坏疽性脓皮病及其溃疡性表现（溃疡性假上皮瘤病）的黏膜类似物。PSV 与炎症性肠病（IBD）之间存在很强的相关性已得到充分证实。PSV 病变的组织病理学通常显示棘层肥厚，以及中性粒细胞和/或嗜酸性粒细胞浸润伴上皮内或上皮下脓肿；在某些情况下存在棘层松解。我们研究了 4 例 IBD 患者，他们出现了口腔病变，提示可能为 PSV。纳入了 2 名男性和 2 名女性患者。两名患者的口腔病变组织病理学显示为典型的 PSV 表现。另外两名患者表现为寻常型天疱疮（PV），尽管他们的症状病程与肠道疾病平行。我们的发现可能表明 IBD 患者的脓疱性病变可能是 PSV 和 PV 的表现；需要进行充分的诊断，因为临床表现非常相似。
