Hamed L M, Ellis F D, Boudreault G, Wilson F M, Helveston E M
Am J Ophthalmol. 1987 Jul 15;104(1):50-6. doi: 10.1016/0002-9394(87)90292-3.
Presumed accidental corneal exposure to Hibiclens (chlorhexidine 4% and detergent) in two patients resulted in severe and permanent corneal opacification. We investigated the corneal toxicity of Hibiclens by gross, biomicroscopic, and histopathologic studies of rabbit eyes exposed to Hibiclens for varying time intervals ranging from five to 15 minutes. Severe, irreversible, and progressive corneal damage resulted in all eyes studied.
两名患者疑似意外角膜接触洗必泰醇(4%氯己定和去污剂)后导致严重且永久性角膜混浊。我们通过对暴露于洗必泰醇不同时间间隔(5至15分钟)的兔眼进行大体、生物显微镜和组织病理学研究,来调查洗必泰醇的角膜毒性。所有研究的眼睛均出现了严重、不可逆且进行性的角膜损伤。