Ohrloff C, Duffin M, Apple D J, Olson R J
Am J Ophthalmol. 1984 Oct 15;98(4):422-5. doi: 10.1016/0002-9394(84)90123-5.
Fourteen hydrogel lamellar implants were placed in rabbit corneal stroma. Within six months of implantation, all the rabbit eyes showed some opacification of the cornea, and several of the rabbits had vascularization along the lamellar interface with signs of chronic inflammation. Opacification and vascularization eventually appeared in all 14 eyes, regardless of the water content or oxygen permeability of the lens material. One rabbit was killed, and a histopathologic examination showed evidence of chronic inflammation and scarring. Because the rabbit's sensitivity to an inflammatory nidus makes it a good laboratory test animal, these rabbits' inability to tolerate some of the currently available hydrogel corneal lamellar implants may indicate that such material is unsuitable as a permanent implant for cosmetic refractive surgery in humans.
十四片水凝胶层状植入物被置于兔角膜基质中。植入后六个月内，所有兔眼均出现角膜混浊，部分兔子在层状界面处有血管化并伴有慢性炎症迹象。无论晶状体材料的含水量或透氧性如何，最终所有14只眼睛均出现混浊和血管化。处死一只兔子后进行组织病理学检查，发现有慢性炎症和瘢痕形成的证据。由于兔子对炎症病灶敏感，使其成为良好的实验室测试动物，这些兔子无法耐受一些目前可用的水凝胶角膜层状植入物，这可能表明此类材料不适用于人类美容屈光手术的永久性植入物。
