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奥密克戎变异株流行期间挪威儿童与德尔塔变异株流行期间相比全科医生就诊情况:一项前瞻性全国登记研究。

General practitioner visits after SARS-CoV-2 omicron compared with the delta variant in children in Norway: a prospective nationwide registry study.

机构信息

Cluster for Health Services Research, Norwegian Institute of Public Health, Oslo, Norway.

Division of Paediatric and Adolescent Medicine, University of Oslo, Oslo, Norway.

出版信息

BMJ Paediatr Open. 2022 Aug;6(1). doi: 10.1136/bmjpo-2022-001502.

Abstract

BACKGROUND

SARS-CoV-2 infection in children is followed by an immediate increase in primary care utilisation. The difference in utilisation following infection with the delta and omicron virus variants is unknown.

OBJECTIVES

To study whether general practitioner (GP) contacts were different in children infected with the omicron versus delta variant for up to 4 weeks after the week testing positive.

SETTING

Primary care.

PARTICIPANTS

All residents in Norway aged 0-10. After excluding 47 683 children with a positive test where the virus variant was not identified as delta or omicron and 474 children who were vaccinated, the primary study population consisted of 613 448 children.

MAIN OUTCOME MEASURES

GP visits.

METHODS

We estimated the difference in the weekly share visiting the GP after being infected with the delta or omicron variant to those in the study population who were either not tested or who tested negative using an event study design, controlling for calendar week of consultation, municipality fixed effects and sociodemographic factors in multivariate logistic regressions.

RESULTS

Compared with preinfection, increased GP utilisation was found for children 1 and 2 weeks after testing positive for the omicron variant, with an OR of 6.7 (SE: 0.69) in the first week and 5.5 (0.72) in the second week. This increase was more pronounced for children with the delta variant, with an OR of 8.2 (0.52) in the first week and 7.1 (0.93) in the second week. After 2 weeks, the GP utilisation returned to preinfection levels.

CONCLUSION

The omicron variant appears to have resulted in less primary healthcare interactions per infected child compared with the delta variant.

摘要

背景

儿童感染 SARS-CoV-2 后,立即增加了对初级保健的利用。感染德尔塔和奥密克戎变异株后的利用差异尚不清楚。

目的

研究在感染奥密克戎变异株后长达 4 周内,与感染德尔塔变异株的儿童相比,全科医生(GP)的接触是否存在差异。

设置

初级保健。

参与者

所有年龄在 0-10 岁的挪威居民。在排除了 47683 名病毒变异体未被鉴定为德尔塔或奥密克戎且 474 名接种疫苗的儿童后,主要研究人群包括 613448 名儿童。

主要观察指标

GP 就诊。

方法

我们使用事件研究设计,根据咨询的日历周、市固定效应和多变量逻辑回归中的社会人口因素,估计感染德尔塔或奥密克戎变异株后每周与 GP 就诊的差异,与未检测或检测结果为阴性的研究人群进行比较。

结果

与感染前相比,在感染奥密克戎变异株后 1 周和 2 周,儿童的 GP 就诊率增加,第 1 周的 OR 为 6.7(SE:0.69),第 2 周为 5.5(0.72)。对于感染德尔塔变异株的儿童,这种增加更为明显,第 1 周的 OR 为 8.2(0.52),第 2 周为 7.1(0.93)。2 周后,GP 就诊率恢复到感染前水平。

结论

与德尔塔变异株相比,奥密克戎变异株似乎导致每例感染儿童的初级保健互动减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bad/9421916/28b4e8590587/bmjpo-2022-001502f01.jpg

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