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基于深度学习算法的帕金森病深部脑刺激治疗效果和神经保护作用的磁共振成像图像分析。

Magnetic resonance imaging image analysis of the therapeutic effect and neuroprotective effect of deep brain stimulation in Parkinson's disease based on a deep learning algorithm.

机构信息

Department of Neurosurgery, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

Department of Imaging, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

出版信息

Int J Numer Method Biomed Eng. 2022 Nov;38(11):e3642. doi: 10.1002/cnm.3642. Epub 2022 Aug 30.

DOI:10.1002/cnm.3642
PMID:36054274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9786712/
Abstract

In order to study the therapeutic neuroprotective effect of deep brain stimulation (DBS) in Parkinson's disease (PD), based on the deep learning algorithm, this study combines with magnetic resonance imaging (MRI) image analysis technology to study the clinical efficacy of DBS in the surgical treatment of PD and the neuroprotective and neurological recovery effects after surgery. Establish a deep learning algorithm model based on MRI image analysis technology, comparison of UPDRS motor status assessment and the improvement of daily life ability before and after DBS surgery, evaluate the accuracy rate and the detection speed of the model. The models constructed in this study have an accuracy rate of more than 90% in the PD detection test, and the detection speed of the algorithm model under the condition of big data is between 60 and 200 ms. DBS significantly improve a series of clinical symptoms in patients with PD. The deep learning algorithm model based on MRI image analysis technology in this paper has a certain effect. DBS operation can improve the symptoms of PD, and has the effect of neuroprotection and neurological recovery.

摘要

为了研究深部脑刺激（DBS）在帕金森病（PD）中的治疗神经保护作用，本研究基于深度学习算法，结合磁共振成像（MRI）图像分析技术，研究 DBS 在 PD 手术治疗中的临床疗效及术后的神经保护和神经功能恢复效果。建立基于 MRI 图像分析技术的深度学习算法模型，比较 DBS 手术前后 UPDRS 运动状态评估及日常生活能力的改善情况，评估模型的准确率和检测速度。本研究构建的模型在 PD 检测试验中的准确率均在 90%以上，大数据条件下算法模型的检测速度在 60~200ms 之间。DBS 可明显改善 PD 患者的一系列临床症状。本文基于 MRI 图像分析技术的深度学习算法模型具有一定的效果。DBS 手术可以改善 PD 症状，具有神经保护和神经功能恢复作用。

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Surgical Treatment of Parkinson Disease.帕金森病的外科治疗
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Optimal Elevator Group Control via Deep Asynchronous Actor-Critic Learning.基于深度异步演员-评论家学习的最优电梯群控
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