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地塞米松抑制试验与创伤后应激障碍

The DST and posttraumatic stress disorder.

作者信息

Kudler H, Davidson J, Meador K, Lipper S, Ely T

出版信息

Am J Psychiatry. 1987 Aug;144(8):1068-71. doi: 10.1176/ajp.144.8.1068.

DOI:10.1176/ajp.144.8.1068
PMID:3605429
Abstract

The dexamethasone suppression test (DST) was administered to 28 male combat veterans with posttraumatic stress disorder. Six subjects (21%) were nonsuppressors. The nonsuppression rates for the subgroups with and without major depressive disorder according to the Research Diagnostic Criteria were 50% and 6%, respectively. The authors conclude that cortisol nonsuppression is rare in posttraumatic stress disorder unless there is concomitant major depression.

摘要

对28名患有创伤后应激障碍的男性退伍军人进行了地塞米松抑制试验(DST)。6名受试者(21%)为非抑制者。根据研究诊断标准,伴有和不伴有重度抑郁症的亚组的非抑制率分别为50%和6%。作者得出结论,除非同时伴有重度抑郁症,否则创伤后应激障碍患者中皮质醇非抑制情况很少见。

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引用本文的文献

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Questioning the link between PTSD and cognitive dysfunction.质疑创伤后应激障碍与认知功能障碍之间的联系。
Neuropsychol Rev. 2003 Dec;13(4):221-35. doi: 10.1023/b:nerv.0000009485.76839.b7.
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Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder.创伤后应激障碍患者脑脊液中促肾上腺皮质激素释放因子浓度升高。
Am J Psychiatry. 1997 May;154(5):624-9. doi: 10.1176/ajp.154.5.624.