Section of Pediatric Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, 10 McClennan Banks Drive, MSC 918, Charleston, SC 29425, USA.
Department of Comparative Medicine, Medical University of South Carolina, 114 Doughty St., Room 640, Charleston, SC 29425, USA.
Transplant Rev (Orlando). 2022 Dec;36(4):100725. doi: 10.1016/j.trre.2022.100725. Epub 2022 Aug 27.
Pigs, or Sus scrofa domestica, are commonly used animal models in translational transplantation research due to their anatomical, physiological, and immunological similarities to humans. In solid organ transplantation studies, immunosuppressive medications may be administered to pigs to prevent rejection. We provide an overview of the immunosuppressive regimens used in allogeneic solid organ transplantation in pigs, including heart, lung, kidney, bowel and cotransplanted organs and focus on the use of tacrolimus, mycophenolate mofetil, and corticosteroids.
猪，即家猪（Sus scrofa domestica），由于其在解剖学、生理学和免疫学方面与人类的相似性，通常被用作转化移植研究的动物模型。在实体器官移植研究中，可能会给猪使用免疫抑制剂来预防排斥反应。我们提供了猪同种异体实体器官移植中使用的免疫抑制方案概述，包括心脏、肺、肾脏、肠道和共移植器官，并重点介绍了他克莫司、霉酚酸酯和皮质类固醇的使用。
