Division of Pediatric Cardiovascular Surgery, Arkansas Children's Hospital, Little Rock, Arkansas, USA.
Artif Organs. 2024 Apr;48(4):326-335. doi: 10.1111/aor.14664. Epub 2023 Oct 18.
Heart valves serve a vital hemodynamic function to ensure unidirectional blood flow. Additionally, native heart valves serve biological functions such as growth and self-repair. Heart valve implants mimic the hemodynamic function of native heart valves, but are unable to fulfill their biological functions. We developed partial heart transplantation to deliver heart valve implants that fulfill all functions of native heart valves. This is particularly advantageous for children, who require growing heart valve implants. This invited review outlines the past, present and future of partial heart transplantation.
心脏瓣膜具有确保单向血流的重要血液动力学功能。此外，天然心脏瓣膜还具有生长和自我修复等生物学功能。心脏瓣膜植入物模拟天然心脏瓣膜的血液动力学功能，但无法发挥其生物学功能。我们开发了部分心脏移植来递送能够发挥天然心脏瓣膜所有功能的心脏瓣膜植入物。这对于需要不断生长的心脏瓣膜植入物的儿童来说尤其有利。本文邀请专家对部分心脏移植的过去、现在和未来进行了综述。
