Wilson J F, Rausch R L, McMahon B J, Schantz P M, Trujillo D E, O'Gorman M A
Am J Trop Med Hyg. 1987 Jul;37(1):162-8. doi: 10.4269/ajtmh.1987.37.162.
Albendazole was administered preoperatively to two patients with active alveolar hydatid disease for 58 and 84 days. Vesicles of larval Echinococcus multilocularis obtained from surgical tissues were inoculated into red-backed voles for in vivo testing viability. No proliferation of the larval cestode had occurred when the animals were dissected three months post-inoculation. These findings suggest that short-term therapy with albendazole was effective in killing the larval cestode in these two cases. Albendazole was found to be hepatotoxic but resulting transaminase abnormalities have been reversible. Close monitoring of liver function and hematology is essential in patients under albendazole therapy.
对两名患有活动性肺泡型包虫病的患者在术前给予阿苯达唑治疗，疗程分别为58天和84天。将从手术组织中获取的多房棘球绦虫幼虫囊泡接种到红背田鼠体内进行活力的体内测试。接种三个月后解剖动物时，未见幼虫绦虫增殖。这些发现表明，在这两例病例中，阿苯达唑短期治疗可有效杀死幼虫绦虫。发现阿苯达唑具有肝毒性，但由此导致的转氨酶异常是可逆的。在接受阿苯达唑治疗的患者中，密切监测肝功能和血液学指标至关重要。
