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本文引用的文献

1
Continuous albendazole therapy in alveolar echinococcosis: long-term follow-up observation of 20 cases.连续使用阿苯达唑治疗泡型包虫病：20 例长期随访观察。
Trans R Soc Trop Med Hyg. 2009 Aug;103(8):768-78. doi: 10.1016/j.trstmh.2009.04.006. Epub 2009 May 19.
2
Close relationship between clinical regression and specific serology in the follow-up of patients with alveolar echinococcosis in different clinical stages.不同临床阶段肺泡型棘球蚴病患者随访中临床消退与特异性血清学之间的密切关系。
Am J Trop Med Hyg. 2009 May;80(5):792-7.
3
Development of an immunochromatographic test to detect antibodies against recombinant Em18 for diagnosis of alveolar echinococcosis.开发一种免疫层析试验以检测抗重组Em18抗体用于肺泡型棘球蚴病的诊断。
J Clin Microbiol. 2009 Jan;47(1):252-4. doi: 10.1128/JCM.01476-08. Epub 2008 Nov 5.
4
Echinococcosis: serological detection of patients and molecular identification of parasites.棘球蚴病：患者的血清学检测及寄生虫的分子鉴定
Future Microbiol. 2007 Aug;2(4):439-49. doi: 10.2217/17460913.2.4.439.
5
Comparison of several commercial serologic kits and Em18 serology for detection of human alveolar echinococcosis.几种商业血清学检测试剂盒与Em18血清学检测在人体肺泡型棘球蚴病检测中的比较
Diagn Microbiol Infect Dis. 2007 Sep;59(1):93-5. doi: 10.1016/j.diagmicrobio.2007.03.018. Epub 2007 May 16.
6
Imaging aspects and non-surgical interventional treatment in human alveolar echinococcosis.人体肺泡型棘球蚴病的影像学表现及非手术介入治疗
Parasitol Int. 2006;55 Suppl:S267-72. doi: 10.1016/j.parint.2005.11.053. Epub 2006 Jan 5.
7
Progress in diagnosis, treatment and elimination of echinococcosis and cysticercosis.棘球蚴病和囊尾蚴病在诊断、治疗及消除方面的进展。
Parasitol Int. 2006;55 Suppl:S7-S13. doi: 10.1016/j.parint.2005.11.050. Epub 2006 Jan 4.
8
The present situation of echinococcosis in Europe.欧洲棘球蚴病的现状。
Parasitol Int. 2006;55 Suppl:S187-91. doi: 10.1016/j.parint.2005.11.028. Epub 2005 Dec 13.
9
Medical treatment of echinococcosis under the guidance of Good Clinical Practice (GCP/ICH).在《药物临床试验质量管理规范》（GCP/ICH）指导下的棘球蚴病的医学治疗。
Parasitol Int. 2006;55 Suppl:S273-82. doi: 10.1016/j.parint.2005.11.040. Epub 2005 Dec 9.
10
Usefulness of recombinant Em18-ELISA to evaluate efficacy of treatment in patients with alveolar echinococcosis.重组Em18-ELISA在评估肺泡型棘球蚴病患者治疗效果中的应用价值。
J Gastroenterol. 2005 Apr;40(4):426-31. doi: 10.1007/s00535-004-1559-7.

用重组 Em18 对多器官受累的泡型包虫病进展进行血清学监测。

Serological monitoring of progression of alveolar echinococcosis with multiorgan involvement by use of recombinant Em18.

机构信息

Department of Parasitology, Asahikawa Medical College, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510 Hokkaido, Japan.

出版信息

J Clin Microbiol. 2009 Oct;47(10):3191-6. doi: 10.1128/JCM.01111-09. Epub 2009 Aug 5.

DOI:10.1128/JCM.01111-09
PMID:19656973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2756934/
Abstract

Two cases of alveolar echinococcosis (AE) with multiple-organ involvement (the liver, lungs, and bone) were monitored by imaging and serology for 20 years. Resection of the bone lesion was complete in one case but incomplete in the other case. Albendazole treatment was markedly to moderately effective against hepatic and pulmonary AE lesions in both cases, whereas it had almost no effect against the bone lesion in one case. The results of the serological tests with recombinant Em18 antigen coincided with the clinical findings in each case. An enzyme-linked immunosorbent assay for the detection of immunoglobulin G (IgG) responses, especially IgG4 responses, is expected to be a real-time indicator of the dynamics of active AE.

摘要

两例细粒棘球蚴病（AE）伴多器官受累（肝脏、肺部和骨骼），通过影像学和血清学监测 20 年。1 例骨病变完全切除，另 1 例不完全切除。阿苯达唑治疗对两例肝、肺 AE 病变均有明显至中度疗效，而对 1 例骨病变几乎无效。重组 Em18 抗原血清学检测结果与各病例的临床发现相符。酶联免疫吸附试验（ELISA）检测 IgG 反应，特别是 IgG4 反应，有望成为 AE 活动的实时指标。