Bolding O T
Urology. 1978 Sep;12(3):321-4. doi: 10.1016/0090-4295(78)90397-7.
Efficacy and safety of cefadroxil, a new oral cephalosporin, were compared with that of cephalexin in the treatment of 28 women with acute urinary tract infections. According to a randomized double-blind design, each patient received cefadroxil 1,000 mg. twice daily or cephalexin 500 mg. four times a day for ten days. Cures based on urine culture five to nine days post-treatment were obtained for all but 1 patient receiving cefadroxil; reinfection after eradication of the original pathogen was recorded for only 1 patient in each treatment group. No drug-related side effects or significant clinical laboratory abnormalities were observed during the study. Cefadroxil 1,000 mg. given twice daily was as effective and as well tolerated as cephalexin 500 mg. given four times daily. The significance of this dosage schedule advantage is discussed.
将一种新型口服头孢菌素头孢羟氨苄的疗效及安全性与头孢氨苄进行比较，以治疗28例急性尿路感染的女性患者。按照随机双盲设计，每位患者接受每日两次、每次1000mg的头孢羟氨苄治疗，或每日四次、每次500mg的头孢氨苄治疗，疗程为十天。除1例接受头孢羟氨苄治疗的患者外，所有患者在治疗后五至九天的尿培养结果均显示治愈；每个治疗组仅1例患者在根除原始病原体后出现再次感染。研究期间未观察到与药物相关的副作用或显著的临床实验室异常。每日两次给予1000mg头孢羟氨苄与每日四次给予500mg头孢氨苄的疗效及耐受性相当。本文讨论了这种给药方案优势的意义。
