Hausman M S
Urology. 1980 Jan;15(1):40-3. doi: 10.1016/0090-4295(80)90537-3.
The efficacy and tolerability of cefadroxil were assessed in a controlled comparison of high-compliance oral dosage regimens among 100 patients with urinary tract infections. Each patient was randomly assigned to one of three cefadroxil treatment groups: 2,000 mg. once daily, 1,000 mg. once daily, or 1,000 mg. twice daily. Urine cultures at five to nine days post-treatment revealed cures in 27 of 36 patients in the 2,000-mg. daily group, 32 of 36 patients in the 1,000-mg. daily group, and 27 of 28 patients taking 1,000 mg. twice daily. Recurrence rates were extremely low in all treatment groups, and only 3 patients had evidence of limited side effects. The benefits of a convenient and readily understood dosage schedule are discussed.
在100例尿路感染患者中，对头孢羟氨苄的高依从性口服给药方案进行了对照比较，评估了其疗效和耐受性。每位患者被随机分配到三个头孢羟氨苄治疗组之一：每日一次2000毫克、每日一次1000毫克或每日两次1000毫克。治疗后5至9天的尿培养结果显示，每日2000毫克组的36例患者中有27例治愈，每日1000毫克组的36例患者中有32例治愈，每日两次服用1000毫克的28例患者中有27例治愈。所有治疗组的复发率都极低，只有3例患者有轻微副作用的迹象。文中讨论了方便且易于理解的给药方案的益处。
