University of Colorado School of Medicine, Aurora, CO, USA.
Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Sci Rep. 2022 Sep 2;12(1):14932. doi: 10.1038/s41598-022-19095-7.
IgA plays an important early neutralizing role after SARS-CoV-2 infection. Systemically administered vaccines typically produce an IgM/IgG predominant response. We evaluated the serum anti-spike (anti-S) IgG, anti-nucleocapsid (anti-N) IgG and anti-S IgA response following vaccination against SARS-CoV-2 in a cohort of first-responders. Among the 378 completely vaccinated participants, 98% were positive for anti-S IgG and 96% were positive for anti-S IgA. Nine percent were positive for anti-N IgG suggesting prior exposure to SARS-CoV-2. No statistically significant difference was seen in IgA response based on prior evidence infection (p = 0.18). Ninety-eight of those receiving the Moderna vaccine (98%) were positive for anti-S IgA as compared to 91% of those who received the Pfizer vaccine (p = 0.0009). The high proportion of participants observed to have a positive anti-S IgA response after vaccination suggests that the vaccines elicit a systemic response characterized by elevated levels of both IgG and IgA.
IgA 在感染 SARS-CoV-2 后发挥着重要的早期中和作用。全身给药的疫苗通常会产生 IgM/IgG 优势应答。我们评估了一组急救人员接种 SARS-CoV-2 疫苗后血清中针对刺突蛋白（anti-S）的 IgG、抗核衣壳蛋白（anti-N）的 IgG 和抗-S IgA 的反应。在 378 名完全接种疫苗的参与者中，98%对 anti-S IgG 呈阳性，96%对 anti-S IgA 呈阳性。9%对 anti-N IgG 呈阳性，提示之前曾接触过 SARS-CoV-2。根据先前的感染证据（p=0.18），IgA 应答没有统计学差异。98%接种 Moderna 疫苗的人对 anti-S IgA 呈阳性，而接种 Pfizer 疫苗的人中有 91%对 anti-S IgA 呈阳性（p=0.0009）。接种疫苗后观察到大量参与者的 anti-S IgA 反应呈阳性，这表明疫苗引发了一种全身性反应，其特征是 IgG 和 IgA 水平升高。
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