Department of Medical Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Prostate Cancer Prostatic Dis. 2023 Mar;26(1):25-29. doi: 10.1038/s41391-022-00583-w. Epub 2022 Sep 2.
The incidence of prostate cancer is the second most among male cancers after lung cancer. Prostate cancer develops rapidly and is inclined to metastasize, and castration-resistant prostate cancer (CRPC) can be formed in the later stage, which brings great challenges to the prognosis and treatment. At present, the main treatment of prostate cancer is generally divided into four methods: surgery, chemotherapy, radiotherapy and endocrine therapy. However, the efficacy of these methods fails to satisfy the demands of patient prognosis. Ferroptosis is a newly discovered iron-dependent process, characterized by lipid peroxidation. Ferroptosis is associated with many diseases, especially tumor growth. In recent years, inhibiting tumor growth and overcoming tumor drug resistance by inducing ferroptosis has become a hot research topic. Previous studies have shown that induction of ferroptosis may be a new treatment for prostate cancer. We review the research progress of ferroptosis in prostate cancer in order to provide highly effective therapies for patients with prostate cancer.
前列腺癌的发病率在男性癌症中仅次于肺癌，位居第二。前列腺癌发展迅速，易发生转移，晚期可形成去势抵抗性前列腺癌（CRPC），给预后和治疗带来极大挑战。目前，前列腺癌的主要治疗方法一般分为手术、化疗、放疗和内分泌治疗四种，但这些方法的疗效均未能满足患者预后的需求。铁死亡是一种新发现的铁依赖性过程，其特征是脂质过氧化。铁死亡与许多疾病有关，特别是肿瘤的生长。近年来，通过诱导铁死亡抑制肿瘤生长和克服肿瘤药物耐药性已成为研究热点。既往研究表明，诱导铁死亡可能是治疗前列腺癌的一种新方法。我们对铁死亡在前列腺癌中的研究进展进行综述，以期为前列腺癌患者提供更有效的治疗方法。
