Pediatric Department, "Vittore Buzzi" Children's Hospital, Milan, Italy.
Primary Care Pediatrician, ASST Ovest Milan, ATS MILAN, Milan, Italy.
Ital J Pediatr. 2022 Sep 2;48(1):158. doi: 10.1186/s13052-022-01351-1.
Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessel vasculitis, typical of childhood. It's a self-limiting disease and it affects different systems. HSP is characterized by dermatological, abdominal, joint and renal clinical manifestations. This condition usually occurs upon infections, mainly upper respiratory tract ones, medications, vaccinations and malignancies.
We describe the case of a 11 year-old girl who developed a urticarial rash 12 days after the first dose of Pfizer-BioNTech BNT16B2b2 mRNA vaccine and a clear picture of Henoch Schönlein purpura 5 days after administration of the second dose of the same vaccine.
To our knowledge, this is the first description of a pediatric patient with Henoch-Schönlein purpura occurring in association with vaccination against COVID-19.
过敏性紫癜（HSP）是一种 IgA 介导的小血管血管炎，多见于儿童。它是一种自限性疾病，会影响不同的系统。HSP 的特征是皮肤、腹部、关节和肾脏的临床表现。这种情况通常发生在感染后，主要是上呼吸道感染，药物、疫苗接种和恶性肿瘤。
我们描述了一例 11 岁女孩的病例，她在接种辉瑞-BioNTech BNT16B2b2 mRNA 疫苗第一剂后 12 天出现荨麻疹皮疹，在接种第二剂后 5 天出现明确的过敏性紫癜表现。
据我们所知，这是首例与 COVID-19 疫苗接种相关的儿童过敏性紫癜病例描述。
