Mizerska-Wasiak Małgorzata, Skrzypczyk Piotr, Kisiel Agnieszka, Pańczyk-Tomaszewska Małgorzata, Roszkowska-Blaim Maria
Department of Pediatrics and Nephrology, Medical University of Warsaw.
Pol Merkur Lekarski. 2016 Jun;40(240):377-9.
Henoch-Schönlein purpura (HSP) is the most common pediatric autoimmune vasculitis. Gastrointestinal symptoms of HSP including abdominal pain, diarrhea, and vomiting may precede skin changes by several days. We present diagnostic challenges in two adolescents with HSP and severe abdominal symptoms necessitating surgical intervention before the development of skin changes.
CASE REPORT 1: A 15-year old boy with 7 day history of abdominal pain, and bloody vomiting (1-2 x per day) without diarrhea. A suspicion of acute appendicitis was raised and the boy was operated on the 7th day since the initial symptoms. The appendix showed some reactive inflammation and was removed during laparotomy which also revealed enlarged mesenteric lymph nodes and a modest amount of fluid in the pelvic cavity. During the first day after the surgery, skin changes typical for HSP developed on lower limbs and buttocks.
CASE REPORT 2: A 12-year old girl with 7 day history of abdominal pain, without diarrhea or vomiting. On the day of admission hemorrhagic rash appeared on lower limbs. Laparotomy was performed on 14th day after onset of abdominal pain - large amounts of serous, blood-stained fluid, massive dilation of small intestine with ecchymoses in mucous membrane, segmental infiltration and stiffening of intestinal wall were found. Normal appendix was removed.
Severe abdominal symptoms may precede skin changes in children with HSP, resulting in diagnostic and therapeutic challenges. When considering laparotomy in children with an atypical "acute abdomen" presentation, other manifestations of HSP should be sought.
过敏性紫癜(HSP)是最常见的儿童自身免疫性血管炎。HSP的胃肠道症状包括腹痛、腹泻和呕吐,可能在皮肤改变前数天出现。我们报告了两名患有HSP且有严重腹部症状的青少年的诊断挑战,他们在皮肤改变出现之前需要手术干预。
病例报告1:一名15岁男孩,有7天腹痛病史,伴有血性呕吐(每天1 - 2次),无腹泻。怀疑为急性阑尾炎,自最初症状出现后第7天进行了手术。阑尾显示有一些反应性炎症,在剖腹手术中被切除,手术还发现肠系膜淋巴结肿大和盆腔有少量液体。术后第一天,下肢和臀部出现了HSP典型的皮肤改变。
病例报告2:一名12岁女孩,有7天腹痛病史,无腹泻或呕吐。入院当天下肢出现出血性皮疹。腹痛发作后第14天进行了剖腹手术,发现大量浆液性、血性液体,小肠大量扩张,黏膜有瘀斑,肠壁节段性浸润和变硬。正常阑尾被切除。
HSP患儿可能在皮肤改变之前出现严重腹部症状,这带来了诊断和治疗挑战。当考虑对表现为非典型“急腹症”的儿童进行剖腹手术时,应寻找HSP的其他表现。