脐带间充质干细胞治疗脊髓损伤的最佳移植策略：基于动物研究的系统评价和网络荟萃分析。
The optimal transplantation strategy of umbilical cord mesenchymal stem cells in spinal cord injury: a systematic review and network meta-analysis based on animal studies.
机构信息
Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, No.600 Tianhe Road, Guangzhou, 510630, Guangdong, China.
National Medical Products Administration (NMPA) Key Laboratory for Quality Research and Evaluation of Cell Products, Guangzhou, 510630, China.
出版信息
Stem Cell Res Ther. 2022 Sep 2;13(1):441. doi: 10.1186/s13287-022-03103-8.
OBJECTIVE
Umbilical cord mesenchymal stem cells (UCMSCs) have great potential in the treatment of spinal cord injury. However, the specific therapeutic effect and optimal transplantation strategy are still unclear. Therefore, exploring the optimal treatment strategy of UCMSCs in animal studies by systematic review can provide reference for the development of animal studies and clinical research in the future.
METHODS
Databases of PubMed, Ovid-Embase, Web of Science, CNKI, WanFang, VIP, and CBM were searched for the literature in February 11, 2022. Two independent reviewers performed the literature search, identification, screening, quality assessment, and data extraction.
RESULTS AND DISCUSSION
A total of 40 animal studies were included for combined analysis. In different subgroups, the results of traditional meta-analysis and network meta-analysis were consistent, that is, the therapeutic effect of high-dose (≥ 1 × 10) transplantation of UCMSCs was significantly better than that of low dose (< 1 × 10), the therapeutic effect of local transplantation of UCMSCs was significantly better than that of intravenous transplantation, and the therapeutic effect of subacute transplantation of UCMSCs was significantly better than that of acute and chronic transplantation. However, in view of the inherent risk of bias and limited internal and external validity of the current animal studies, more high-quality, direct comparison studies are needed to further explore the optimal transplantation strategy for UCMSCs in the future.
目的
脐带间充质干细胞（UCMSCs）在脊髓损伤治疗中具有巨大的潜力。然而，其确切的治疗效果和最佳移植策略仍不清楚。因此，通过系统评价探讨 UCMSCs 在动物研究中的最佳治疗策略，可以为未来动物研究和临床研究的发展提供参考。
方法
检索 2022 年 2 月 11 日PubMed、Ovid-Embase、Web of Science、CNKI、万方、维普及 CBM 数据库，由 2 位独立研究者进行文献检索、筛选、评价和数据提取。
结果与讨论
共纳入 40 项动物研究进行合并分析。在不同亚组中，传统的荟萃分析和网络荟萃分析结果一致，即 UCMSCs 高剂量（≥1×10）移植的治疗效果明显优于低剂量（<1×10），UCMSCs 局部移植的治疗效果明显优于静脉移植，UCMSCs 亚急性移植的治疗效果明显优于急性和慢性移植。然而，鉴于目前动物研究固有的偏倚风险和有限的内部和外部有效性，未来需要更多高质量、直接比较的研究来进一步探索 UCMSCs 的最佳移植策略。
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