Kay E D, Condon K
Anat Rec. 1987 May;218(1):1-4. doi: 10.1002/ar.1092180102.
Experimental bipedalism in rats has been proposed as a model for studying evolutionary and orthopedic change. This study quantified the skeletal changes which occur in the hindlimbs of these bipedal rats. Bipedalism was produced in 16 male rats by forelimb amputation during the neonatal period. The rats were sacrificed at maturity and the femurs and tibia-fibulas from randomly selected hindlimbs were weighed and measured. Out of a total of 25 parameters, only one, anteroposterior diameter of the proximal femur, was found to differ statistically between the bipedal and control groups. No changes were found in bone length, weight, or curvature. The results of other bipedal studies were reviewed, in light of these findings; and it is concluded that rats do not achieve true bipedalism, or increased hindlimb loading.
大鼠实验性双足行走已被提议作为研究进化和骨科变化的模型。本研究量化了这些双足大鼠后肢发生的骨骼变化。在新生期对16只雄性大鼠进行前肢截肢以产生双足行走。大鼠成熟后处死，对随机选择的后肢的股骨和胫腓骨进行称重和测量。在总共25个参数中，仅发现双足组和对照组之间近端股骨的前后径这一个参数存在统计学差异。未发现骨长度、重量或曲率有变化。根据这些发现对其他双足研究的结果进行了综述；得出的结论是，大鼠并未实现真正的双足行走或后肢负荷增加。
