Department of Sense Organs, Sapienza University, Rome, Italy.
Integrated Head and Neck care Department, Polyclinic Umberto I, Rome, Italy.
Curr Rheumatol Rev. 2023;19(2):159-167. doi: 10.2174/1573397118666220903123128.
The association between KFD and autoimmune diseases, not only with systemic lupus erythematosus, has been repeatedly described.
The aim of this review is to evaluate whether an overlap syndrome is present between KFD and autoimmune diseases, whether there is a chronological and a casual relationship between the pathologies.
The databases used for the overlap case search were Medline and Embase from which we extrapolated the studies of interest. The search queries used were: Kikuchi-Fujimoto Syndrome and juvenile idiopathic arthritis or systemic lupus erythematosus or Systemic Sclerosis or Antiphospholipid Syndrome or Sjogren's Syndrome. All study types were considered (n = 103).
Total number of included studies are 43. We have shown that there is an "overlap" syndrome between KFD and other autoimmune diseases. The chronology of disease onset was variable; autoimmune disease may be "preceding" (n = 11 cases) or "simultaneous" (n = 20 cases) or "post" (n = 8 cases). Kikuchi-Fujimoto Syndrome. Also, the autoimmune disease can present with a complete clinical picture or only with the presence of autoantibodies.
the different pathologies associated with KFD with different chronologies would suggest that there is an alteration of the immune system that allows the pathologies to occur in different temporal relationships.
KFD 与自身免疫性疾病的关联，不仅与系统性红斑狼疮有关，已被反复描述。
本综述旨在评估 KFD 与自身免疫性疾病之间是否存在重叠综合征，以及这些病理学之间是否存在时间和因果关系。
我们使用 Medline 和 Embase 数据库来搜索重叠病例，并从中提取了相关的研究。使用的搜索查询包括：Kikuchi-Fujimoto 综合征和幼年特发性关节炎或系统性红斑狼疮或系统性硬化症或抗磷脂综合征或干燥综合征。考虑了所有研究类型（n=103）。
共纳入 43 项研究。我们表明 KFD 与其他自身免疫性疾病之间存在“重叠”综合征。疾病发病的时间顺序是可变的；自身免疫性疾病可能是“先于”（n=11 例）或“同时”（n=20 例）或“后于”（n=8 例）出现。Kikuchi-Fujimoto 综合征。此外，自身免疫性疾病可能表现为完整的临床表现，也可能仅表现为自身抗体的存在。
与 KFD 相关的不同病理具有不同的时间顺序，这表明免疫系统发生了改变，从而允许这些病理学以不同的时间关系发生。
