Strum D P, Eger E I, Johnson B H, Steffey E P, Ferrell L D
Anesth Analg. 1987 Aug;66(8):769-73.
Sevoflurane, an experimental potent volatile anesthetic with a low blood/gas partition coefficient, degrades in the presence of soda lime to products the toxicity of which is unknown. We tested whether toxic products were produced by the passage of sevoflurane through soda lime, and a comparison was made of the toxicity of sevoflurane passed through soda lime with the toxicity of other potent volatile anesthetics in current clinical use. Halothane, isoflurane, sevoflurane (all in 1-MAC concentrations), or no anesthetic (control) were passed through soda lime for 4 hr with 12, 14, or 100% oxygen to groups of rats with hepatic microsomal enzyme induction. Separate groups of 12-13 rats were given 1 MAC of sevoflurane that had not passed through soda lime and either 14 or 100% oxygen. Sevoflurane was no more toxic than isoflurane and both of these anesthetics were less toxic than halothane. Soda lime was not a factor in any toxicity produced. Hepatic injury with all agents varied inversely with the oxygen concentration administered during anesthesia.
七氟醚是一种实验性的强效挥发性麻醉剂，血/气分配系数低，在碱石灰存在下会降解为毒性未知的产物。我们测试了七氟醚通过碱石灰是否会产生有毒产物，并将通过碱石灰的七氟醚的毒性与目前临床使用的其他强效挥发性麻醉剂的毒性进行了比较。将氟烷、异氟醚、七氟醚（均为1-最低肺泡有效浓度）或无麻醉剂（对照）与12%、14%或100%的氧气一起通过碱石灰4小时，给予肝微粒体酶诱导的大鼠组。另外几组12 - 13只大鼠给予未通过碱石灰的1最低肺泡有效浓度的七氟醚和14%或100%的氧气。七氟醚的毒性不高于异氟醚，且这两种麻醉剂的毒性均低于氟烷。碱石灰不是所产生的任何毒性的影响因素。所有药物引起的肝损伤与麻醉期间给予的氧气浓度呈反比。
