Strum D P, Johnson B H, Eger E I
Department of Anesthesia, University of California, San Francisco 94143.
Anesthesiology. 1987 Nov;67(5):779-81. doi: 10.1097/00000542-198711000-00024.
Stability of halogenated volatile anesthetic is important because of the potential toxicity associated with the breakdown products. The authors enclosed 100 ml of gas containing sevoflurane with 100 g of soda lime in a 581-ml flask for periods up to 24 h. The rate of degradation of sevoflurane by soda lime was several-fold greater than previously reported, and the degradation was temperature-dependent. At 22 degrees C, soda lime degraded 6.5% of the sevoflurane per hour. The rate increased by 1.6% per hour per degree rise in temperature, reaching 57.4% degradation per hour at 54 degrees C. In contrast, isoflurane was not degraded by soda lime. Halothane did not degrade at 22 degrees C or 37 degrees C, but did degrade (2.2% per hour) at 54 degrees C.
由于卤化挥发性麻醉剂的分解产物具有潜在毒性，其稳定性很重要。作者将100毫升含七氟醚的气体与100克碱石灰置于一个581毫升的烧瓶中，放置长达24小时。碱石灰对七氟醚的降解速率比之前报道的高几倍，且降解与温度有关。在22摄氏度时，碱石灰每小时降解6.5%的七氟醚。温度每升高一度，降解速率每小时增加1.6%，在54摄氏度时达到每小时57.4%的降解率。相比之下，异氟醚不会被碱石灰降解。氟烷在22摄氏度或37摄氏度时不会降解，但在54摄氏度时会降解（每小时2.2%）。
