Department of Urology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, China.
Department of Urology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, China.
Biomed Pharmacother. 2022 Oct;154:113594. doi: 10.1016/j.biopha.2022.113594. Epub 2022 Aug 31.
Long non-coding RNAs (lncRNAs) play a critical role in several human diseases, particularly in solid tumors. Specific lncRNAs are effective biological molecular markers for diagnosing diseases and determining patient prognosis for designing molecularly targeted therapies. HOTAIR is reportedly involved in several physiological emerging processes in solid tumor, such as unlocking phenotypic plasticity, polymorphic microbiome, and cellular senescence, and has been implicated in tumorigenesis and progression. This review summarizes the relationship between the levels of expression, biological features, clinical symptoms, and regulatory mechanisms of HOTAIR action in solid cancers and discusses the clinical applicability of HOTAIR as a biomarker for predicting risk, diagnosis, prognosis, and designing targeted therapy for cancer.
长链非编码 RNA（lncRNAs）在多种人类疾病中发挥着关键作用，特别是在实体肿瘤中。特定的 lncRNAs 是诊断疾病和确定患者预后以设计分子靶向治疗的有效生物分子标志物。据报道，HOTAIR 参与了实体肿瘤中的几个生理新兴过程，如解锁表型可塑性、多态微生物组和细胞衰老，并与肿瘤发生和进展有关。本综述总结了 HOTAIR 在实体癌中的表达水平、生物学特征、临床症状和作用调节机制之间的关系，并讨论了 HOTAIR 作为预测风险、诊断、预后和设计癌症靶向治疗的生物标志物的临床适用性。
