Department of Dermatology, Calcutta National Medical College and Hospital, Kolkata, India.
Department of Dermatology, FAAMCH, Barpeta, India.
J Cosmet Dermatol. 2022 Dec;21(12):7018-7024. doi: 10.1111/jocd.15353. Epub 2022 Sep 30.
Xanthelasma palpebrarum (XP) primarily causes cosmetic disfigurement. However, systemic associations like metabolic syndrome (MetS) and dyslipidemia need consideration.
Determining the prevalence of MetS and dyslipidemia in XP patients and explore risk factors.
Our case-control study included 106 XP patients(cases) and 106 age-and-sex matched healthy controls. All subjects underwent detailed history taking, physical examination, and biochemical investigations. MetS and obesity were diagnosed by NCEP-ATP III criteria and modified BMI classification for Asian-Indians, respectively.
The odds ratio (OR) and 95% CI for XP patients vs. non-XP controls were 1.6 (95% CI 0.8-3.2, p = 0.1) for MetS, 1.4 (95% CI 0.6-3.1, p = 0.4) for dyslipidemia and 0.2 (95% CI 0.07-0.4, p < 0.0001) for overweight/obesity. Extensive disease, DM, and low serum HDL-C were significantly associated with MetS in XP patients (vs. controls). Normal waist circumference (AOR 21.3, 95% CI 3.5-127.6, p = 0.0008), normal blood glucose (AOR 21.4, 95% CI 3.1-145.1, p = 0.002), and normal blood pressure (AOR 22.3, 95% CI 3.9-124.9, p = 0.0004) significantly reduced the risk of MetS, while bilateral ocular involvement (AOR 4.3, 95% CI 1.1-18.7, p = 0.04) significantly increased the risk of dyslipidemia in XP patients.
Xanthelasma palpebrarum patients are more prone to develop MetS and dyslipidemia and need evaluation, despite being a primarily cosmetic concern. Extensive disease and bilateral ocular involvement are significant risk factors. Adequate counseling and healthy life-style measures are crucial to minimize systemic complications.
眼睑黄色瘤（XP）主要导致美容缺陷。然而，需要考虑代谢综合征（MetS）和血脂异常等全身关联。
确定 XP 患者中 MetS 和血脂异常的患病率，并探讨相关风险因素。
我们的病例对照研究纳入了 106 例 XP 患者（病例）和 106 名年龄和性别匹配的健康对照者。所有受试者均接受详细的病史询问、体格检查和生化检查。MetS 和肥胖症通过 NCEP-ATP III 标准和改良的 BMI 分类（适用于亚洲印度人）进行诊断。
XP 患者与非 XP 对照组相比，MetS 的优势比（OR）和 95%置信区间（CI）为 1.6（95%CI 0.8-3.2，p=0.1），血脂异常为 1.4（95%CI 0.6-3.1，p=0.4），超重/肥胖为 0.2（95%CI 0.07-0.4，p<0.0001）。广泛的疾病、糖尿病和低血清 HDL-C 与 XP 患者的 MetS 显著相关（与对照组相比）。正常腰围（AOR 21.3，95%CI 3.5-127.6，p=0.0008）、正常血糖（AOR 21.4，95%CI 3.1-145.1，p=0.002）和正常血压（AOR 22.3，95%CI 3.9-124.9，p=0.0004）显著降低了 MetS 的风险，而双侧眼部受累（AOR 4.3，95%CI 1.1-18.7，p=0.04）则显著增加了 XP 患者血脂异常的风险。
尽管 XP 主要是美容问题，但眼睑黄色瘤患者更容易发生 MetS 和血脂异常，需要进行评估。广泛的疾病和双侧眼部受累是显著的风险因素。充分的咨询和健康的生活方式措施对于最大限度地减少全身并发症至关重要。
