Kou Lieling, Liu Weishai, Zhu Xiaoyan, Wan Wanyu, Wang Manhua
Department of Ophthalmology, Ankang Hospital of Traditional Chinese Medicine, Ankang, Shaanxi Province, China.
Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China.
Medicine (Baltimore). 2025 Jul 4;104(27):e43223. doi: 10.1097/MD.0000000000043223.
Medicated thread moxibustion (MTM), an integral component of traditional Chinese medicine, has, however, seen limited evidence regarding its application in treating xanthelasma palpebrarum (XP) in practical settings. This study was designed with the objective of evaluating both the efficacy and safety of MTM in the treatment of XP. A retrospective analysis was conducted on 79 patients with XP treated with MTM at a single center. The degree of lesion clearance, number of treatment sessions, adverse events, tolerability, and recurrence rate were assessed. By the final visit, 22 patients (28%) had achieved complete lesion clearance, while 54 patients (68%) exhibited significant improvement, with over 50% of their lesions cleared. Three patients (4.0%) experienced <50% clearance, indicating no significant therapeutic effect. The median number of treatment sessions required was 3.0, with an interquartile range of 2.0 to 5.0. Over half of the patients (51, 64.6%) achieved either excellent clearance or a satisfactory response within the initial 3 treatment sessions. Participants experienced tolerable itching or burning sensations, which obviated the need for anesthesia. No severe adverse events, including infection, atrophy, scarring, hyperpigmentation, or discoloration, were reported. However, in 3 patients (13.6%), lesions recurred within 1 year post-complete clearance. MTM suggests to be an effective and safe alternative for treating XP, featuring a low recurrence rate. Prospective randomized controlled trial studies are necessary to explore the mechanism and efficacy of this treatment method.
药线灸（MTM）是中医的一个重要组成部分，然而，在实际应用中，其治疗睑黄瘤（XP）的证据有限。本研究旨在评估药线灸治疗睑黄瘤的疗效和安全性。对在单一中心接受药线灸治疗的79例睑黄瘤患者进行回顾性分析。评估病变清除程度、治疗次数、不良事件、耐受性和复发率。到最后一次随访时，22例患者（28%）病变完全清除，54例患者（68%）有显著改善，超过50%的病变清除。3例患者（4.0%）清除率<50%，表明无明显治疗效果。所需治疗次数的中位数为3.0，四分位间距为2.0至5.0。超过一半的患者（51例，64.6%）在最初3次治疗中达到了极佳的清除效果或满意的反应。参与者经历了可耐受的瘙痒或烧灼感，无需麻醉。未报告包括感染、萎缩、瘢痕形成、色素沉着或变色在内的严重不良事件。然而，3例患者（13.6%）在病变完全清除后1年内复发。药线灸似乎是治疗睑黄瘤的一种有效且安全的替代方法，复发率低。有必要进行前瞻性随机对照试验研究，以探索这种治疗方法的机制和疗效。
